Exceptional Association of a Common Variable Immunodeficiency and Ankylosing Spondylitis: A Case Report

Abstract

We report a new observation of an unusual association of CVID with ankylosing spondylitis (AS). Osteoarticular involvement associated with CVID occurs in approximately 5 to 40% of cases, most commonly in the form of septic arthritis, or non-septic arthritis, which is part of the joint manifestations of autoimmune and rheumatic diseases associated with CVID. A 53-year-old patient with a history of recurrent bronchopulmonary infections complicated by bronchial dilatation since the age of 38, pelvic-axial syndrome and peripheral inflammatory arthralgia affecting the large and medium-sized joints and enthesitis (talalgia), who has presented since the age of 40 with a digestive disorder consisting of chronic liquid diarrhoea with 6 stools a day, developing in the context of a deterioration in her general condition, without any mention of medication. Regarding biotherapy, in particular anti-TNF alpha, this is the first-line biotherapy for APS. It has been shown to be effective in patients with CVID with joint involvement in the course of granulomatous disease, which would be beneficial for our patient.