Efficacy and Reliability of Matrix PRP in Erectile Dysfunction Therapy: Experience of the Regenerative Medicine Center at CHEIKH KHALIFA University Hospital, Morocco

Abstract

Introduction: Platelet-rich plasma is defined as a plasma fraction derived from autologous blood with a platelet concentration above the normal range.  It constitutes a reservoir of bioactive proteins, mainly growth factors, which are essential for initiating and accelerating tissue repair and regeneration. Biological stimulation of damaged tissue with platelet concentrates (PRP) involves harnessing the tissue's regenerative potential by recruiting local stem cells. Methods: This is a retrospective study spread over 12 months (March 2021 to March 2022) involving a sample of 40 patients with erectile dysfunction with an age ranging from 34 to 71 years and an average of 52.5 years. Initial assessment and follow-up of patients was based on the International Index of Erectile Function (IIEF5) with a score of (5-10) indicating severe erectile dysfunction, (11-15) moderate, (16-20) mild, (21-25) no erectile dysfunction. Results: All in all, a significant improvement in IEF5 was demonstrated in all patients, with the mean IEF5 of all patients rising uniformly after each dose, plateauing at months 3 and 6. Conclusion: The IEF5 of 55% of patients improved after the 1st dose, with 70% of patients showing improvement after the 2nd dose, then stagnating at 80% after the3rd dose.