UV Derivative Spectrophotometric Method for Determination of Bisoprolol Fumarate in Bulk and Tablet Formulation
Elsadig H. Rudwan, Amna B. W. E. Mohammed, Ahmed E. M. Saeed
International Research Journal of Pure and Applied Chemistry · pp. 1–7 · Published 15 Mar 2017
10.9734/IRJPAC/2017/31256Abstract
Simple, cost effective, accurate and reproducible UV derivative-spectrophotometric method were developed and validated for the estimation of bisoprolol fumarate in pharmaceutical preparations. Bisoprolol fumarate was estimated at 233 nm in 50% methanol. The beer’s law was obeyed in the concentration range of 2.0 –10.0 µg/ml (r2 = 0.9995). The apparent molar absorptivity and Sandall’s sensitivity coefficient were found to be 391 L· mol−1·cm−1 and 2.51-g·cm–2 /0.001 respectively, indicating the high sensitivity of the proposed method. The method was tested and validated for various parameters according to ICH guidelines. The detection and quantitation limits were found to be 0.0267 and 0.0808 μg /ml respectively. The proposed methods were successfully applied for the determination of bisoprolol fumarate in pharmaceutical preparations. The results demonstrated that the procedure is accurate, precise and reproducible (R.S.D. < 2%).
Cited by 2
Eman Yossri Frag, Marwa ELbadry Mohamed, Hanaa A. El-Boraey · International Journal of Electrochemical Science · 2019
Pramod Kumar Goyal, Manish Jaimini · International Journal of Pharmaceutical Chemistry and Analysis · 2023
Related research
- Insecticide Susceptibility Profile of Anopheles gambiae s.l. from Ikot-Ekpene, Akwa Ibom State, Nigeria — shares topic coverage
- Development and Validation of a Complexometric Titration Method for the Determination of Rosuvastatin Calcium in Raw Material — shares topic coverage
- Detection and Assay of Riboflavin (Vitamin B2) Utilizing UV/VIS Spectrophotometer and Citric Acid Buffer — shares topic coverage
- Isolation and Anti-Bacterial Activity of the Active Components from the Stem- -Back of Enantial chlorantha — shares topic coverage
- Analgesic (Antinociceptive) Property of Moringa oleifera Ethanol Leaf Extract in Albino Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
2
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.