Expression of Salivary Resistin in Oral Premalignant Individuals

Abstract

Introduction: Resistin, (Retn) a pro - inflammatory cytokine, accumulates at the site of inflammation. It is found to be elevated in chronic inflammation. The aim of this present study is to evaluate the levels of salivary resistin in healthy individuals and in patients with Oral pre-malignant lesion. Materials and Methods: This case control study comprises of total 90 patients which includes 45 healthy controls and 45 cases diagnosed with oral pre-malignant lesions. Salivary levels of resistin and clinical parameters were evaluated in all of them. Socio - demographic data (age, gender and residence) was collected from all participants through a questionnaire. In addition,  we also recorded the total duration of tobacco usage (in years), daily frequency, and intra-oral examination and oral hygiene practices. This was followed by evaluation of clinical parameters of oral premalignant lesions and investigation of salivary levels of resistin through ELISA. Results: The saliva of all the patients showed presence of resistin. On analyzing the samples present study shows no significant difference and variation in the salivary levels of resistin in healthy and OPML patients. Conclusion: With the results of this study, it can be concluded that there is no significant difference in the salivary levels of resistin in healthy individuals and individuals diagnosed with oral pre-malignant lesion.