Exploring DNA Analysis Methods and Genetic Research Applications in Low and Middle-Income Nations: A Study of Sri Lanka
Prabath Jaythissa, Avanthi Rupasinghe
Asian Journal of Medicine and Health · pp. 54–62 · Published 3 Jun 2024
10.9734/ajmah/2024/v22i71045Abstract
Using Sri Lanka as a case study, the paper explores how DNA analysis has transformed genetic research, particularly in low and middle-income countries (LMICs). It discusses various DNA analyzing techniques, from traditional methods like Sanger sequencing to advanced techniques such as next-generation sequencing (NGS) and CRISPR-Cas9, highlighting their applications in disease research, population genetics, and forensic science. Sri Lanka's advancements in genetic research, including DNA sequencing, typing, and recent developments in X-chromosome-based DNA typing, are emphasized. The paper also examines challenges and opportunities in LMICs regarding genetic research and underscores the importance of DNA analysis in advancing personalized medicine and understanding genetic diversity. Additionally, it discusses Sri Lanka's efforts in education and training in molecular biology. It explores the country's rich genetic diversity and demographic history, focusing on ethnic studies and historical interactions among different population groups. Overall, the paper highlights the significance of DNA analysis in genetic research and its potential implications for LMICs. Sri Lanka is a notable example of progress in the field.
References (23)
- 1 DNA sequencing with chain-terminating inhibitors [DOI]
- 2 A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity [DOI]
- 3 Development and Applications of CRISPR-Cas9 for Genome Engineering [DOI]
- 4 [21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction [DOI]
- 5 Coming of age: ten years of next-generation sequencing technologies [DOI]
- 6 Next-generation DNA sequencing [DOI]
- 7 Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase [DOI]
- 8 mRNA-Seq whole-transcriptome analysis of a single cell [DOI]
- 9 Real-Time DNA Sequencing from Single Polymerase Molecules [DOI]
- 10 Accurate whole human genome sequencing using reversible terminator chemistry [DOI]
- 11 Next-Generation DNA Sequencing Methods [DOI]
- 12 Reconstructing Indian population history [DOI]
- 13 The Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics community [DOI]
- 14 Fluorescence detection in automated DNA sequence analysis [DOI]
- 15 The Technology and Biology of Single-Cell RNA Sequencing [DOI]
- 16 Genomics-assisted breeding for crop improvement [DOI]
- 17 Disease gene identification strategies for exome sequencing [DOI]
- 18 Progress in Ion Torrent semiconductor chip based sequencing [DOI]
- 19 Third-generation sequencing fireworks at Marco Island [DOI]
- 20 Bioinformatics Analysis on DNA Barcode Sequences for Species Identification: A Review [DOI]
- 21 DNA Profiling Advances in Forensic Dentistry- A Review [DOI]
- 22 Review on Next Generation Sequencing [DOI]
- 23 Review on Single DNA Sequencing [DOI]
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