Evaluation of the Hepatic effects of Caladium hortulanum Leaf Extract on Wistar Albino Rats
International Research Journal of Pure and Applied Chemistry · pp. 23–28 · Published 6 Aug 2022
10.9734/irjpac/2022/v23i430470Abstract
This study evaluates the hepatic effects of caladium hortulanum leaf extract on wistar albino rats. A total of twenty-four (24) rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well-ventilated room. Group A served as control and these rats were fed distilled water. Rats in the groups B, C, and D were given three (3) different doses of the leaf extract (1.5, 3.5 and 5.0mL/Kgbw) respectively. They were administered once daily for 14 and 28 days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. All liver enzymes and histology results were normal for short term use in this study. Alkaline phosphatase was increased in a dose dependent manner when used in the long term. Histopathological changes were seen in all doses when Caladium hortulanum leaf extract was used in the long term. This suggests that this medicinal plant cause some degree of hepatic damage when used for continuously for long periods at a time. Care should therefore be taken with their use, prescriptions reviewed as needed and regular monitoring of liver function should be instituted.
References (12)
- 1 Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa [DOI]
- 2 Medicinal plants: An invaluable, dwindling resource in sub-Saharan Africa [DOI]
- 3 Pharmacoinformatic Investigation of Medicinal Plants from East Africa [DOI]
- 4 Insights of antidiabetic, anti-inflammatory and hepatoprotective properties of antimicrobial secondary metabolites of corm extract from Caladium x hortulanum [DOI]
- 5 Socio-economic implications of COVID-19 pandemic in Nigeria [DOI]
- 6 Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats [DOI]
- 7 Estimation of Toxicity Level of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on some Serum Lipid Profile Parameters and the Heart of Wister Albino Rats
- 8 Phytochemical Composition, Antimicrobial and Antioxidant Activities of Leaves and Tubers of Three Caladium Species
- 9 Nutrient Composition, Mineral and Anti-Nutrient Components of Processed Wild Cocoyam (Caladium Bicolor, (Ait) Vent) [DOI]
- 10 Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats [DOI]
- 11 The Socio-Economic Effects of Covid-19 Global Pandemic on Nigeria’s Development
- 12 Medicinal plants of the world [DOI]
Cited by 0
No indexed citations yet.
Related research
- Studies on Green Synthesis of Copper Nanoparticles Using Punica granatum — shares topic coverage
- Selenium Priming Selectively Ameliorates Weed – Induced Phytotoxicity by Modulating Antioxidant Defense Components in Lentil (Lens culinaris Medik.) and Grass Pea (Lathyrus sativus L.) — shares topic coverage
- Effects of Moringa (Moringa Oleifera) Leaf Extract on Growth, Yield and Yield Components of Snap Beans (Phaseolus vulgaris) — shares topic coverage
- Doxorubicin-Induced Cardio Toxicity in Albino Rats Protected by Adansonia Digitata (Baobab) Leaf Extract — shares topic coverage
- Phytochemical Screening, Polyphenol Content and Antioxidant Studies of Ethanol Leaf Extract of Combretum aculeatum vent. — shares topic coverage
Article metrics
Real usage data collected on this platform.
13
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.