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Research Article Open access CC BY 4.0

Doxorubicin-Induced Cardio Toxicity in Albino Rats Protected by Adansonia Digitata (Baobab) Leaf Extract

Akintola Adebola Olayemi, Kehinde Busuyi David, Saka Waheed Adeoye, Oyewande Esther Ajoke, Ayandiran Tolulope Akinpelu, Ogundiran Mathew Akinloye

Annual Research & Review in Biology · pp. 12–22 · Published 13 Jul 2021

10.9734/arrb/2021/v36i730395

Abstract

Cardiovascular disease is the world's leading cause of death, killing 17 to 19 million people each year. The usage of traditional drugs was influenced by the need for effective medications for the treatment of cardiovascular disease without side effects. The current study investigated the cardio-protective effects of Adansonia digitata leaf extract on doxorubicin-mediated cardiotoxicity in laboratory rats. Thirty-five albino rats were divided into five groups, each consisting of seven rats. Group 1 was given filtered water as a control, while Group 2 was given saline and doxorubicin, Group 3 received doxorubicin and Vitamin E, and Groups IV and V were myocardial oxidative animals treated with Adansonia digitata leaf extract (150 and 300 mg/kg/wt) for two weeks. After the rats were sacrificed, their hearts were collected and homogenized for biochemical assays. The results on the activities of creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate amino transferase (AST), nitric oxide synthase (NOS), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde were determined. Histopathology examination was used in addition to assays to validate myocardial damage. In comparison to the control group, rats provided doxorubicin showed a significant increase in the activities of cardiac marker enzymes (CK, LDH, and AST), as well as a significant increase in malondialdehyde concentration with a concomitant decrease in antioxidant enzymes (SOD, CAT, and NOS), implying cardiotoxicity. In rats with doxorubicin-induced myocardial infection, pretreatment with Adansonia digitata leaf extract reduced myocardial damage, these biochemical results were confirmed by histopathology. Finally, the new study demonstrates that Adansonia digitata has cardioprotective properties.

Cardiovascular disease Adansonia digitata doxorubicin cardiotoxicity leaf extract

References (25)

  1. 1 The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase [DOI]
  2. 2 Methods of Enzymatic Analysis [DOI]
  3. 3 Underlying Causes and Long-Term Survival in Patients with Initially Unexplained Cardiomyopathy [DOI]
  4. 4 Doxorubicin Cardiomyopathy [DOI]
  5. 5 The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide [DOI]
  6. 6 People's Plants: A Guide to Useful Plants of Southern Africa
  7. 7 Effect of anthracycline antibiotics on oxygen radical formation in rat heart.
  8. 8 Martindale : the complete drug reference
  9. 9 Endothelial Nitric Oxide Synthase-Dependent Superoxide Generation from Adriamycin [DOI]
  10. 10 Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity [DOI]
  11. 11 Baobab Food Products: A Review on their Composition and Nutritional Value [DOI]
  12. 12 Use of medicinal plants for the treatment of oral diseases in Burkina Faso [DOI]
  13. 13 Anthracycline-Induced Suppression of GATA-4 Transcription Factor: Implication in the Regulation of Cardiac Myocyte Apoptosis [DOI]
  14. 14 Evaluation of mineral elements and ascorbic acid contents in fruits of some wild plants [DOI]
  15. 15 The Amino Acid and Mineral Content of Baobab (Adansonia digitata L.) Leaves [DOI]
  16. 16 Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy [DOI]
  17. 17 Glycosidase Inhibitory Flavonoids from Sophora flavescens [DOI]
  18. 18 Myocardial adrenergic changes at two stages of heart failure due to adriamycin treatment in rats [DOI]
  19. 19 Regulatory role of glutathione and soluble sulfhydryl groups in the toxicity of adriamycin. [DOI]
  20. 20 The effect of doxorubicin on hepatic and cardiac glutathione.
  21. 21 Biochemical determinants of adriamycin® toxicity in mouse liver, heart and intestine [DOI]
  22. 22 High-performance liquid chromatographic determination of vitamin C in fresh fruits from West Africa [DOI]
  23. 23 The nutritive value of Baobab fruit (Adansonia digitata).
  24. 24 Repair kinetics of DNA, RNA and proteins in the tissues of mice treated with doxorubicin.
  25. 25 The baobabs: pachycauls of Africa, Madagascar and Australia [DOI]

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