Evaluation of safety of Arohi Snehapana (Incremental Oleation Therapy) Over Physical, Hematological and Biochemical Parameters in Healthy Volunteers

Abstract

Background: Ayurveda strongly recommends the Panchakarma (Purification or detoxification therapies), e.g., Vamana (Therapeutic emesis) & Virechana (Therapeutic purgation) etc., in healthy persons for the prevention of the diseases & maintenance of the health. Vamana & Virechana are preceded by the Arohi Snehapana (Incremental oleation) compromising of intake of specific lipid in a large quantity. As it facilitates the smooth conduction of these procedures & brings bio-toxins in the systemic circulation for their easy elimination through these procedures;therefore it is the mandatory criteria before these procedures. However, there is apprehension about its lipid elevating effect; therefore, there is quite a restriction in its acceptability in the current cholesterol-sensitive era. Ultimately, people hesitate to undergo Shodhana measures & they get deprived of their miraculous results. Aim and Objective: Considering these hurdles, the current study was planned to evaluate and assess the safety effects of Arohi Snehapana over physical, hematological, and biochemical parameters in healthy volunteers. Materials and Methods: This is a single-centric, open-labeled clinical trial in which a total of 50 healthy volunteers (both male & female) were recruited. All volunteers were selected by purposive sample method & were prescribed Incremental oleation with cow ghee before Shodhana therapy for a maximum of 7 days or till achievement of proper oleation features, whichever is earlier. All volunteers were assessed for physical (weight, B.M.I.), hematological & biochemical parameters before & just after the intervention. Result and Observations: In this study, Bodyweight declined significantly by 3-4 kg (1.47%. ) for (P<0.001) within 1-7 days of an intervention despite using a good amount of fat (Go-Ghrita). Blood urea was significantly decreased by 12.63 % (for p-Value <0.001), but this decrease was absolutely within the normal range. Significant reduction in blood urea after invention proves the role of Snehapana to reduce overload over the kidney and perform the protective role. No significant elevation in lipid profile due to this intervention. Conclusion: The current study evaluates the efficacy of Incremental oleation with respect to various proper oleation features and its safety over physical, hematological, and biochemical parameters in healthy volunteers.