Evaluation of Potential Drug-drug Interactions in Prescription in Outpatient Department of Tertiary Care Hospital

Abstract

Aims: To evaluate potential drug- drug interactions (pDDIs) in prescriptions generated in outpatient department. Study Design:  A cross sectional, observational study. Place and Duration of Study: Pharmacy store, Government Medical College & Hospital, Nagpur, between July 2022 to September 2022. Methodology: Cross Sectional study performed in outpatient department from July 2022 to September 2022 analysed 382 patient prescriptions (Male : Female 1.41 : 1.0 ; Mean Age 33.67 ± 23.18 ) to evaluate for potential DDIs. Precription with atleast 2 drugs were included in the analysis. Data was analysed for potential drug- drug interactions using Rx list drug interaction checker Online, an online software to check drug-drug interactions (https://www.rxlist.com/drug-interaction-checker.htm) available on the website. Descriptive statistics were performed using MS Excel 2019. Results: Of the 382 (Male: Female 1.41 : 1.0 ; Mean Age 33.67 ± 23.18 )prescriptions analysed for potential DDIs , 55 prescription were found to have potential DDIs. In those 55 prescriptions, 73 potential DDIs were identified. Conclusion: Incidence of potential drug- drug interactions was found to be 14.39%  in these study.