Evaluation of Non-HDL-C and Calculated Lipid Profile Ratios among Pre-Diabetic Individuals

Abstract

Introduction: The worldwide prevalence of diabetes mellitus is rapidly increasing. The major concern is the complexity and mortality that are secondary to the complications of diabetes mellitus. One among the complications is dyslipidaemia which leads to atherosclerotic diseases. Pre-diabetes is a mid-state between non-diabetes and diabetes mellitus. They have a greater chance of progressing into the disease. Dyslipidaemia, a major aetiological factor for atherosclerosis, is also noted in pre-diabetic stage, report studies. This study was a cross-sectional study involving 26 non-diabetic controls, 26 prediabetic and 26 diabetic cases. The participants were of 18-45 years of age. The data was collected over a period of three months. The groups were classified based on their HbA1c concentration. The blood samples were analysed for fasting lipid profile and the parameters, Non-HDL-C, TC/HDL-C and LDL-C/HDL-C obtained by using respective methods. The obtained lipid profile parameters, Non-HDL-C, TC/HDL-Cand LDL-C/HDL-C were found to be increased in pre-diabetic subjects and diabetic subjects when compared to the healthy non-diabetic controls. The parameters also showed a positive correlation and was statistically highly significant among the three groups. There was a positive association observed among the groups for the calculated lipid profile parameters, Non-HDL-C, TC/HDL-C and LDL-C/HDL-C and were found to be directly proportional  to  HbA1c.