Skip to content
Research Article Open access CC BY 4.0

Evaluation of Chenopodium Quinoa Extract on Diazepam Induced Memory Impairment in Animal Models

M. Ganga Raju, Triyasha Mondal, N. V. L. Suvarchala Reddy V., M. Anila

Journal of Advances in Medical and Pharmaceutical Sciences · pp. 39–52 · Published 27 Dec 2021

10.9734/jamps/2021/v23i1130270

Abstract

Aim: The present study explored the pharmacological and insilico studies of ethanolic seed extract of Chenopodium quinoa. Materials and Methods: The screening of in vivo anti- amnesic activity of the ethanolic seed extract of Chenopodium quinoa was carried out using Actophotometer and Rotarod apparatus. The extract exhibited active constituents like myristic acid, palmitic acid, eicosadienoic acid, pentadecanoic acid, tocopherols, stigmasterol, β-sitosterol, quercetin, benzoic acid, kaempferol, arachidonic acid, benzofuran and 2-bromodecanoic acid. In silico approaches like docking studies (Mcule software) and Ramchandran plot (procheck), online softwares were used in the study to establish mechanism of action of active constituents present in the extract. Results: The extract treated groups at doses (200 mg/kg and 400 mg/kg, bd.wt) showed significant anti-amnesic activity. The basal activity score in actophotometer is as an indicator for impairment of learning and memory. Fall of time by rotarod is used to evaluate learning and memory in rodent models of CNS disorders as in case of amnesia. The results revealed that quercetin, kaempferol, myristic acid, palmitic acid, stigmasterol, lenolenic acid, pentadecanoic acid, tocopherols, arachidonic acid and standard donepezil have got highest glide scores against selected Protein Data Bank (PDB ID): 1EVE, 2FY4, 7CUM and 3EJ8. According to Ramachandran plot a good quality model would be expected to have over 90% in the most favoured region. Proteins like PDB ID: 1EVE, 2FY4, 7CUM and 3EJ8 showed almost 80-90% favoured region which clearly indicates that the selected proteins in the present study are of good quality. Conclusion: Our research unveiled that ethanolic seed extract of Chenopodium quinoa possessed significant anti- amnesic activity.

Chenopodium quinoa Protein Data Bank (PDB) docking studies Mcule software and Ramachandran plot.

References (10)

  1. 1 Techniques for extraction and isolation of natural products: a comprehensive review [DOI]
  2. 2 Nutrition facts and functional potential of quinoa ( Chenopodium quinoa willd.), an ancient Andean grain: a review [DOI]
  3. 3 Alpha-Linolenic Acid: An Omega-3 Fatty Acid with Neuroprotective Properties—Ready for Use in the Stroke Clinic? [DOI]
  4. 4 Prevalence of dementia in India: A systematic review and meta-analysis [DOI]
  5. 5 Efficacy of bacopa monnieri (Brahmi) and Donepezil in Alzheimer's Disease and mild cognitive impairment: A randomized double-blind parallel Phase 2b study [DOI]
  6. 6 Neuroprotective effect of red quinoa seeds extract on scopolamine-induced declarative memory deficits in mice: The role of acetylcholinesterase and oxidative stress [DOI]
  7. 7 Anti-Amnesic Effect of Methanolic Leaf Extract of Tecoma stans: An Experimental Study in Rodents [DOI]
  8. 8 COGNITIVE ENHANCING, ANTI ACETYLCHOLINESTERASE AND ANTIOXIDANT PROPERTIES OF TAGETES ERECTA AGAINST DIAZEPAM INDUCED AMNESIA IN RODENTS [DOI]
  9. 9 Diazepam-induced amnesia: a neuropharmacological model of an "organic amnestic syndrome" [DOI]
  10. 10 GC-MS Analysis, Gastroprotective and In Silico Docking Studies of Phytoconstituents from Ixora Javanica Flowers [DOI]

Cited by 5

Insightful Valorization of Biological Activities of Flax Seed (Linum usitatissimum) through Experimental and Computer Aided Mechanisms

M. Ganga Raju, Charitha Burri, N. V. L. Suvarchala Reddy V · Journal of Complementary and Alternative Medical Research · 2022

Quinoa and Moringa Seeds Extracts Mitigated Endoplasmic Reticulum Stress, Mitochondrial Dysfunction, and Neuronal Toxicity Induced by TiO2-Nanoparticles in Rats

Ayat A. Mohamed El-Rayes, Hanaa M. Abd El-fattah, N. El-Rahmany · Letters in Applied NanoBioScience · 2026

Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development

N. Slimani, Soumaya Arraouadi, H. Hajlaoui · Pharmaceuticals · 2025

Showing 3 of 5 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

35

Page views

0

PDF downloads

3

Outbound clicks

5

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.