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Research Article Open access CC BY 4.0

Evaluation of Anti-Inflammatory Activities of Aqueous and Ethanolic Extracts of Gomphrena celosioides Linn.

Gogahy Konan, Aka Ayebe Edwige, Yeo Dodehe, J. Djaman Allico, F. Yapo Adou, D. N’guessan Jean, F. Yapi Houphouet

International Journal of Biochemistry Research & Review · pp. 127–134 · Published 16 Oct 2014

10.9734/IJBCRR/2015/13353

Abstract

Aims: This study was therefore aimed to evaluate potential anti-inflammatory activity of Aqueous and Ethanolic extracts of Gomphrena celosioides (C. Mart) and to determine the most active extract in rat. Study Design: Gomphrena celosioides was collected from Bingerville, District of Abidjan (Cote d’Ivoire). The plant was identified and authenticated by the “Centre National de Floristique”, University Felix Houphouet Boigny, Cocody. Place and Duration of Study: Analysis on the plant samples were done at the ‘’Laboratoire de Pharmacodynamie-Biochimique, UFR Biosciences, Université de Cocody-Abidjan (Côte d’Ivoire), and Institut Pasteur de Côte d’Ivoire, Département de Biochimie médicale & fondamentale’’ between September 2013 and June 2014. Methodology: The anti-inflammatory activities were investigated by utilizing carrageenan induced paw edema and CRP concentration in rat. These extracts were administrated intraperitoneally at differents doses (100 and 200mg/kg body weight) to rats. Result: The present study showed a significant anti-inflammatory activity at 200mg/kg. b.w. to both extracts which were comparable to the Diclofenac (10mg/kg) inhibition. However, the inflammation inhibition is raised more than 2.6% with the ethanolic extract when this comparison is made with the aqueous extract. This study showed an increased CRP concentration (p <0.05) at rats treated with carrageenan with regard to extracts and Diclofenac rats groups. But there is no significant difference between CRP concentration with extracts and diclofenac rats groups (p>0.05). Conclusion: This study showed that aqueous and ethanolic extracts of Gomphrena celosioides have a potential anti-inflammatory properties. However, this anti-inflammatory activity is more raised with ethanolic extract and seems to have the most active extract. So, ethanolic and aqueous extracts can be utilized for therapeutic purposes.

Gomphrena celosioides anti-inflammatory carrageenan diclofenac CRP

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Cited by 5

Antioxidant Activity of Phenolic Compounds Biosynthesized by Plants and Its Relationship With Prevention of Neurodegenerative Diseases

Janne Rojas, Alexis Buitrago · Bioactive Compounds · 2019

<i>Review Paper</i> : Providing credence to the ethnomedicinal value of <i>Gomphrena celosioides</i> Mart: a systematic review

Daniel Boison, Derrick Owusu, Robertson Akrofi · International Journal of Biological and Chemical Sciences · 2025

Gomphrena celosioides Mart.: A review of traditional uses, phytochemistry and pharmacology

Ankita Rani, Jiten Singh, Sakir · Pharmacological Research - Natural Products · 2025

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