Evaluation of Anti-hyperlipidemic Effect of Aqueous Leaves Extract of Moringa oleifera in Alloxan Induced Diabetic Rats
T. A. Oyedepo, S. O. Babarinde, T. A. Ajayeoba
International Journal of Biochemistry Research & Review · pp. 162–170 · Published 3 May 2013
10.9734/IJBCRR/2013/3639Abstract
Aims: The purpose of this study is to evaluate the effect of aqueous leaf extract of Moringa oleifera (Moringaceae) on plasma glucose level, total cholesterol level, triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in male albino rats. Study Design: Experimental method was adopted. Place and Duration of Study: Adeleke University, Ede, Nigeria and University of Ibadan, Nigeria between September 2012 and January, 2013. Methodology: Twenty-four male albino rats of the Wistar strain weighing between 160 and 200 g were used for this study. These were randomly assigned into 3 groups of 8 animals per group as normal control, diabetic control and diabetic treated with extract of Moringa oleifera. Diabetes was induced by 100 mg/kg of alloxan monohydrate. The control and the diabetic groups received distilled water while the diabetic treated group was administered 400 mg/kg body weight of aqueous leaf extract of Moringa oleifera for 28 days. At the end of the experiment, plasma glucose level, cholesterol, Triglycerides (TG), High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) were determined in all the experimental animals after 12 hours fast. Results: The result showed significant increases (P<0.05) in plasma cholesterol, TG and LDL level of the diabetic control group when compared with the normal control group while there were no significant differences in the Moringa oleifera -treated diabetic group and the normal control group. The HDL however was not different in all the three groups. Conclusion: Oral administration of aqueous leaf extract of Moringa oleifera may reduce the plasma lipid imbalances associated with diabetes mellitus.
Cited by 30
A. L. Ayobami, E. A. Kade, K. A. Oladimeji · 2020
Getaye Tessema Desta, Yared Andargie Ferede, Woretaw Sisay Zewdu · Evidence-Based Complementary and Alternative Medicine · 2022
Mohamed Hamed, Nasser S. Abou Khalil, Alshaimaa A.I. Alghriany · Heliyon · 2024
Hirdayesh Anuragi, Rajesh Kumar Singhal, Yashfa Tanveer · Phyton · 2022
Rasha M. Reda, Rania M. A. Helmy, Ali Osman · Environmental Science and Pollution Research · 2023
Olubukola Sinbad Olorunnisola, Peter Ifeoluwa Adegbola, Bamidele Stephen Ajilore · Medicines · 2021
Varun Kumar, Amarjeet Kumar, Gulzar Ahmad Nayik · Antioxidants in Vegetables and Nuts - Properties and Health Benefits · 2020
Amira Abd El Latif, Badr El Said El Bialy, Hamada Dahi Mahboub · Biochemistry and Cell Biology · 2014
Mohamed Ahmed Hassan, Tao Xu, Yang Tian · Phytomedicine · 2021
Faridi Shabnam, Isha Rani, Dhiman Vivek · Current Traditional Medicine · 2023
Showing 22 of 30 known citations — external sources report more than can currently be individually listed.
Related research
- Hepatic, Pancreatic, and Renal Histo-Morphologic Alterations in Administration of Aqueous and Ethanol Seed Extract of Buchholzia coriacea in Alloxan-Induced Diabetic Rats — shares topic coverage
- Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats — shares topic coverage
- Cardiovascular and Blood Glucose Adaptation during Ramadan Fasting among Different Weight Status Subjects — shares topic coverage
- Sleep Duration in Children and Its Influence on Glucose Homeostasis, Ingestive Behavior and Primary Examination Performance — shares topic coverage
- Crude Aloe vera Gel Reduces Small Intestinal Transit and Increases Body Weight in Normal Albino Wistar Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
57
Page views
0
PDF downloads
3
Outbound clicks
30
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.