Epidemiology of Mansonella perstans and Loa loa: Prevalence and Specific Risk Factors in Njombe-Penja Health District, Littoral Region of Cameroon

Abstract

Aim: This epidemiological survey aimed to determine the prevalence and specific risk factors of Mansonella perstans and Loa loa infections in the Njombe-Penja Health District of Cameroon. This region is endemic for filarial infections, posing significant public health burden. Study Design: A cross-sectional study was conducted among 360 participants, representing various occupational groups and areas of settlements. Place and Duration of Study: The study was conducted in the Njombe-Penja Health District of the Littoral Region of Cameroon. Recruitment of participants, biological samples collection and questionnaire administration was done over a period of 1 month (July 2023). Methodology: Fifty microliters (50 µL) of peripheral blood was collected using capillary tubes, and analyzed for microfilarial presence and load. Structured questionnaires were used to collect data on demographic characteristics, exposure to risk factors, and preventive practices. Descriptive statistics, Chi-square tests with p-values, and odds ratios were calculated to identify significant associations. Results: The results showed a prevalence of 45.8% for M. perstans and 19.4% for L. loa, with higher infection rates among farmers, especially those working in the large scale banana farming sector, and those living near water bodies (P = .002, OR = 3.15). Poor environmental sanitation (P = .004, OR = 2.75), and low monthly income (< 50,000 CFA) (P = .001, OR = 2.32), were also significantly associated with increased infection risk. Although 70.0% of participants were aware of the diseases, only 50.0% could identify key symptoms. Preventive measures like using bed nets and insect repellents were linked to a lower risk of infection (P =.003, OR = 2.10). Conclusion: Mansonella perstans and L. loa infections are highly prevalent in the district, driven by occupational exposure, socioeconomic factors, and environmental risks. Interventions should focus on improving sanitation, enhancing public health education, and expanding healthcare access.