Efficacy and Safety of Triamcinolone Injection in Keloid

Abstract

Background: A keloid scar is characterised by the production of type III (early) or type I (late) collagen. The goal of this study was to see how effective intralesional triamcinolone acetonide was in treating Keloids from a clinical and microscopic standpoint. Methods: This prospective study included 40 patients diagnosed clinically and histologically with Keloid. Patients were given intralesional injection of triamcinolone (40mg / ml) and each 1 cm2 of keloid was injected by 0.3 ml of the solution for one session monthly for five subsequent sessions. Patients were subjected to full history taking, clinical examination [general and dermatological], digital photography of the lesions and tissue punch biopsies. Results: Before treatment: Normal pigmentation occurred in 36(90.0%) and hyper pigmentation occurred in 4(10.0%). After treatment: Normal pigmentation occurred in 32(80.0%), hyper and hypo pigmentation occurred in 4(10.0%). Colour, itching, pliability and surface area were insignificantly different before and after treatment. Conclusions: The triamcinolone injection was to be promising and long lasting for the suppression of symptoms related to keloids and hypertrophic scars.