Effects of Resveratrol on Oxidative DNA Damage Induced by the Acute Swimming Exercise

Abstract

Background: The point of this study was to look at how resveratrol administration affects on intense swimming exercise in oxidative circumstance. The investigation may suggest the administration of resveratrol supplements for athletes who are practice intensely. Methods: In this research, rats were isolated into four groups, and there were eight rats in each group. Group 1 was the control group which was not subjected to any application. Group 2 was the control group subjected to exhaustive exercise. Group 3 was Resveratrol-supplemented swimming group. This group was administered with 10 mg/kg/day Resveratrol intraperitoneally for a month and enforced exhaustive exercise at the end of applications. Group 4 was Resveratrol supplemented general control group which managed with 10 mg/kg/day Resveratrol intraperitoneally for a month and not subjected to exercise toward the finish of the application. Malondialdehyde (MDA), total oxidant levels (TOS), total antioxidant levels (TAS) and eight hydroxy guanosine (8-OhdG) levels were assessed in this study. Results: In this examination, highest MDA levels and TOS in intense swimming exercise were found (p < 0.05). Additionally, intense swimming exercise was caused by DNA damage in mononuclear leukocytes and raised 8-OhdG levels and TAS (p<0.05).   Conclusion: Resveratrol was diminished severity of oxidative DNA damage, genotoxicity and lipid peroxidation of intense swimming exercise. Taking everything into account, resveratrol has ameliorative effects against lipid peroxidation and genotoxicity by expanding antioxidant defence mechanism in rats.