Effects of α-Humulene and its Nanoparticles in Experimental  Model of Alzheimer's Disease: Behavioral Analysis and Anti-Inflammatory Activity

Maria Elvira Ribeiro Cordeiro; Luana Rodrigues Vasconcelos; Heron Bittencourt; Flávio Klinpovous Kerppers; Andressa Panegalli Hosni; Ivo Ilvan Kerppers; Rubiana Mara Mainardes; Christiane Schineider Machado Kolc; Ana Carolina Dorigoni Bini; Patricia Pacheco Tyski Suckow; Eliane Gonçalves de Jesus Fonseca; Angela Dubiela Julik

doi:10.9734/jammr/2023/v35i245318

Research Article Open access CC BY 4.0

Effects of α-Humulene and its Nanoparticles in Experimental Model of Alzheimer's Disease: Behavioral Analysis and Anti-Inflammatory Activity

Maria Elvira Ribeiro Cordeiro, Luana Rodrigues Vasconcelos, Heron Bittencourt, Flávio Klinpovous Kerppers, Andressa Panegalli Hosni, Ivo Ilvan Kerppers, Rubiana Mara Mainardes, Christiane Schineider Machado Kolc, Ana Carolina Dorigoni Bini, Patricia Pacheco Tyski Suckow, Eliane Gonçalves de Jesus Fonseca, Angela Dubiela Julik

Journal of Advances in Medicine and Medical Research · pp. 1–13 · Published 12 Dec 2023

10.9734/jammr/2023/v35i245318

Abstract

The aim was to analyze the effects of α-humulene in experimental models of Alzheimer’s disease (AD). A sample composed of 33 rats, divided into the NC group: 3 animals, for analysis of normal tissue and behavior, PC: 10 animals submitted to induction of AD by application of β-amyloid, without treatment, HUM: 10 animals submitted to induction of AD and treated with α-humulene, and NHUM: 10 animals submitted to induction of AD and treated with α-humulene nanoparticles. Treatment was performed once daily for 14 days at a dose of 6.5µg, orally. The animals were submitted to behavioral tests of spatial memory and aversive memory, the cytokines TNF, IL-10, IL-2 and IL-4 were analyzed by flow cytometry. The treated animals obtained superior cognitive performance and expressed lower levels of inflammatory markers, with better results in the group with better results in the NHUM.

α-humulene Alzheimer's nanoparticles cytokine neuroinflammation

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Maria Elvira Ribeiro Cordeiro, Luana Rodrigues Vasconcelos, Heron Bittencourt, Flávio Klinpovous Kerppers, Andressa Panegalli Hosni, Ivo Ilvan Kerppers, Rubiana Mara Mainardes, Christiane Schineider Machado Kolc, Ana Carolina Dorigoni Bini, Patricia Pacheco Tyski Suckow, Eliane Gonçalves de Jesus Fonseca, Angela Dubiela Julik (2023). Effects of α-Humulene and its Nanoparticles in Experimental Model of Alzheimer's Disease: Behavioral Analysis and Anti-Inflammatory Activity. Journal of Advances in Medicine and Medical Research , 1–13. https://doi.org/10.9734/jammr/2023/v35i245318

Affiliations

Maria Elvira Ribeiro Cordeiro — University of Brasilia, DF, Brazil.
Luana Rodrigues Vasconcelos — Mid-West State University, PR, Brazil.
Heron Bittencourt — Mid-West State University, PR, Brazil.
Flávio Klinpovous Kerppers — Mid-West State University, PR, Brazil.
Andressa Panegalli Hosni — Mid-West State University, PR, Brazil.
Ivo Ilvan Kerppers — Department of Physiotherapy, Mid-West State University, PR, Brazil.
Rubiana Mara Mainardes — Pharmacy School, Mid-West State University, Guarapuava, PR, Brazil.
Christiane Schineider Machado Kolc — Mid-West State University, PR, Brazil.
Ana Carolina Dorigoni Bini — Mid-West State University, PR, Brazil.
Patricia Pacheco Tyski Suckow — Mid-West State University, PR, Brazil.
Eliane Gonçalves de Jesus Fonseca — Mid-West State University, PR, Brazil.
Angela Dubiela Julik — Mid-West State University, PR, Brazil.

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