Effect of Some Haematological, Haemostatic and Inflammatory Markers on Parity in Cervical Cancer Patients in Port Harcourt

Abstract

Most cervical cancers are caused by Human Papillomavirus (HPV), the most common sexually transmitted infection that causes warts in various parts of the body.  Cervical cancer is the second common female malignant tumor globally that seriously threatens females’ health. This study was aimed at determining the effect of some Haematological, Haemostatic and Inflammatory Markers on Parity in cervical cancer patients in Port Harcourt. This study was a case-control study. A total of 40 participants (20 histologically confirmed cervical cancer positive subjects and 20 histologically confirmed cervical cancer negative subjects) within the age of 18-70 years were recruited for this study. The demographics and informed consent of the study subjects were obtained with the use of a questionnaire. Eight millilitres (8mls) of blood sample were collected using vacutainers from each participant. Weight, height and body mass index (BMI) were recorded. Von Willebrand Factor (vWF), thrombomodulin, FVIII, Tissue plasminogen activator, D-dimer and C-reactive protein were analysed using ELISA technique. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were analysed using manual method; fibrinogen was analysed using the coagulation method, plasma viscosity was analysed using capillary viscometer tube method while erythrocyte sedimentation rate (ESR) was analysed using the Westergren tube method. GraphPad Prism 8.0.2.263 version was used for data analysis. Analysis of variance (ANOVA) was used for different groups. P<0.05 was considered significant. Results were presented as mean ± standard deviation (m±SD) in Tables and Figures. This research work also revealed no statistically significant difference in all haematological parameters of cervical cancer patients vs control subjects based on parity. Therefore, parity plays no role in the alteration of haematological parameters as a result of the disease. The study also revealed a statistically significant linear increase in fibrinogen concentration in cervical cancer subjects based on parity. Subjects who have given birth to more than 4 children recorded a significant increase in their fibrinogen concentration. Other parameters indicated no statistically significant difference. This study revealed that parity does not directly play a significant role in cervical cancer disease.