Effect of Salinity on Hyphal Growth and Antimicrobial Potential of Two Halophilic Fungi
Vengatesan Sanjaikumar, Subramaniyan Anbuselvan, Surendrakumar Nabisha, Thangavelu Ramesh, Muthusamy Thangaraj
Journal of Advances in Microbiology · pp. 155–165 · Published 19 Jul 2025
10.9734/jamb/2025/v25i7967Abstract
Halotolerant fungi possess the unique ability to survive and thrive in hypersaline environments, making them promising candidates for the production of bioactive secondary metabolites. This study investigated the effect of varying salinity levels (5–25% NaCl) on the growth, antimicrobial activity, and chemical profile of two halophilic fungal strains, Fusarium oxysporum RAS2 and Aspergillus niger RAS3, previously isolated from the Vellar estuary. Maximum hyphal growth for both strains was observed at 5% NaCl, whereas the highest antibacterial and antifungal activities were recorded at 20% NaCl. Ethyl acetate extracts from cultures grown at this concentration exhibited significant inhibition against Pseudomonas sp. and Candida albicans (F. oxysporum RAS2), and Pseudomonas sp. and Rhizopus sp. (A. niger RAS3). The chemical profile of the fungal crude extracts was studied extensively. These results suggest that salt-induced stress enhances the biosynthesis of potent antimicrobial compounds in halotolerant fungi, underscoring their potential as valuable sources of novel therapeutics.
Cited by 2
G Thirupathi, S Anbuselvan, Vengatesan Sanjaikumar · Journal of Clinical Immunology & Microbiology · 2026
Showing 1 of 2 known citations — external sources report more than can currently be individually listed.
Related research
- Evaluation of Phytochemical Constituents and Antimicrobial Activity of Leaves and Stem Bark Extracts of Sarcocephalus latifolius — shares topic coverage
- Diversity and Antimicrobial Activity of Hydrobionts Associated Microorganisms from the Sea of Japan with the Occurrence of Tropodithietic Acid Producing Bacteria — shares topic coverage
- Antimicrobial Activity of Emilia pratermissa Leaf Extracts on Organisms Isolated from Patients with Otitis Media Attending Federal Medical Centre Owo and Ondo States Specialist Hospital Akure — shares topic coverage
- Molecular Identification, Bioactivity Screening and Metabolic Fingerprinting of the Actinomycetes of Chenab River Sediments — shares topic coverage
- Evaluating Efficacy of Biosurfactants from Bacterial Isolates in Conferring Protection against Rhizoctonia and Sclerotium Infection in Wheat and Peanut Plants — shares topic coverage
Article metrics
Real usage data collected on this platform.
15
Page views
0
PDF downloads
1
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.