Effect of Mining Activities on Some Biochemical Parameters of Opanda-Ugya Inhabitants, Toto Local Government of Nigeria
Mustapha Mohammed Ahmed, Bawa Yusuf Muhammad, Moses Zira Zaruwa, Semiu Olalekan Ajiboso
Asian Journal of Research in Biochemistry · pp. 1–11 · Published 14 Jul 2023
10.9734/ajrb/2023/v13i1245Abstract
Mining activities are usually associated with environmental pollution and the infiltration of toxic heavy metals into waterways which could be absorbed by plants or used by inhabitants. The aim of this research was to determine the effect of mining activities on some biochemical parameters of Opanda-Ugya inhabitants, Toto Local government of Nigeria. Four hundred and fifty (450) people were interviewed using questionnaires. Eighty (80) of them were carefully grouped into four: Group 1(20 Control), Group 2 (20 inhabitants), Group 3 (20 indirect miners) Group 4 (20 direct miners). The Survey discovered some symptoms that could be associated with heavy metal toxicity among the inhabitants. Biochemical assay of blood samples revealed no significant (P ˃0.05) increase in Serum ALT, AST and Total bilirubin in groups 2, 3 and 4 when compared to control, but a decrease in TP. Serum creatinine levels increased significantly in group 3 when compared to the control. Both creatinine and urea levels elevated significantly in group 2 and group 4 when compared with the control. The result of Oxidative stress markers has indicated a significant increase in the levels of MDA with a concomitant decrease in the levels of GSH in groups 2, 3 and 4 compared to the control. The AChE activity in groups 2, 3 and 4 significantly increased when compared to the control. The levels of CRP increased significantly in groups 3 and 4 when compared to the control. We conclude that the neurological and other disorders observed in some participants could be attributed to chronic inflammation and oxidative stress induced by heavy metal toxicity, thus something should be done by the necessary authority to curtail the long-time effect of Mining activities in this community.
References (40)
- 1 [13] Catalase in vitro [DOI]
- 2 DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION [DOI]
- 3 Regulation and Function of NF-κB Transcription Factors in the Immune System [DOI]
- 4 Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants [DOI]
- 5 Lead Exposure and Cardiovascular Disease—A Systematic Review [DOI]
- 6 Superoxide dismutases [DOI]
- 7 Oxidative Stress, Inflammation, and Vascular Aging in Hypertension [DOI]
- 8 Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease [DOI]
- 9 Structural, Chemical and Biological Aspects of Antioxidants for Strategies Against Metal and Metalloid Exposure [DOI]
- 10 Low level lead exposure and oxidative stress: Current opinions [DOI]
- 11 Effect of Heavy Metals on, and Handling by, the Kidney [DOI]
- 12 Nervous System Dysfunction among Workers with Long-Term Exposure to Manganese [DOI]
- 13 Initial CSF total tau correlates with 1-year outcome in patients with traumatic brain injury [DOI]
- 14 Strategies for Safe and Effective Therapeutic Measures for Chronic Arsenic and Lead Poisoning [DOI]
- 15 An ultramicromethod for the determination of conjugated and total bilirubin in serum or plasma [DOI]
- 16 Environmental occurrence, health effects and management of lead poisoning [DOI]
- 17 Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity [DOI]
- 18 Cadmium and health in the 21st Century – historical remarks and trends for the future [DOI]
- 19 Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure [DOI]
- 20 Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes [DOI]
- 21 Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress.
- 22 Involvement of Environmental Mercury and Lead in the Etiology of Neurodegenerative Diseases [DOI]
- 23 Burton’s Line in Lead Poisoning [DOI]
- 24 Heavy metal concentrations in soil and wild plants growing around Pb–Zn sulfide terrain in the Kohistan region, northern Pakistan [DOI]
- 25 Effect of Toxic Metals on Human Health~!2009-12-12~!2010-02-09~!2010-04-06~! [DOI]
- 26 Heavy Metal Sources and Their Effects on Human Health [DOI]
- 27 Toxic Metals and Chronic Kidney Disease: a Systematic Review of Recent Literature [DOI]
- 28 Antioxidant, antiapoptotic, antigenotoxic, and hepatic ameliorative effects of L-carnitine and selenium on cadmium-induced hepatotoxicity and alterations in liver cell structure in male mice [DOI]
- 29 C-reactive protein as a marker of ventilator-associated pneumonia resolution: a pilot study [DOI]
- 30 Determination of an Acute No-Observed-Adverse-Effect Level (NOAEL) for Copper in Water [DOI]
- 31 Hepatoprotective effects of taurine against mercury induced toxicity in rats.
- 32 In vivo effects of metals on the acetylcholinesterase activity of the Perna perna mussel’s digestive gland
- 33 Mechanisms of Rapid Reactive Oxygen Species Generation in Response to Cytosolic Ca2+ or Zn2+ Loads in Cortical Neurons [DOI]
- 34 Legacy of Lead Exposure: Consequences for the Central Nervous System [DOI]
- 35 Zinc and its effects on oxidative stress in Alzheimer’s disease [DOI]
- 36 New diagnostic criteria and management of acute kidney injury [DOI]
- 37 Heavy metal induced alterations in acetylcholinesterase activity of Indian major carps
- 38 Measurement of Total Alkaline Phosphatase Activity in Human Serum using Charcoal Activated Para-Nitro Phenyl Phosphate [DOI]
- 39 Journal of Entomology and Zoology Studies [DOI]
- 40 PRACTICAL CLINICAL BIOCHEMISTRY [DOI]
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