Effect of Beverages on Release of Paracetamol Tablet by In-vitro Dissolution Method Using Modified Media

Abstract

Oral route of drug delivery is one of the most preferred route of drug administration. People often consume oral solids, especially OTC drugs, at any time before or after breakfast with water or any other available hot or cold beverages. Crocin is one of the popular OTC brands of paracetamol, which is preferred in large number. Patient consumes this OTC tablet with available beverages which may be hot or cold. However, beverages interact with paracetamol, affecting the release of drug. In view of this, work was focused on study of the effect of various beverages such as coffee, tea, milk, carbonated drink and buttermilk on release of paracetamol (Crocin tablet) tablet using USP type II dissolution apparatus.  Dissolution media used was modified phosphate buffer (pH 5.8) which was further added with beverages and was analyzed by UV spectrophotometrically. Dissolution profile revealed the maximum drug release 97.03 ± 1.29% in plain water was while minimum with tea 23.64 ± 2.00%. In conclusion, beverages consumed while administering with paracetamol tablet affects the release of drug and therefore should be cautiously used or avoided with dosage forms.