Effect of Aqueous Extract of Cannabis sativa Leaf on the Oxidative Stress Markers in the Brain of Male Wistar Rats
Paul, Demshimeno, Ukoha Ukoha, Ugochukwu Aguwa
Asian Journal of Applied Chemistry Research · pp. 53–62 · Published 11 Jun 2024
10.9734/ajacr/2024/v15i3291Abstract
Cannabis sativa is a commonly abused drug especially among younger people in society. The cerebellum is located at the back of the brain, immediately inferior to the occipital and temporal lobes within the posterior cranial fossa. The study was designed to show the effect of aqueous leave extract of Cannabis sativa on the performance of male Wistar rats in the hanging wire and open field neurobehavioural tests. A total of 40 Wistar rats were used and grouped into five groups. Group A received distilled water for 28 days. Group B, C, D and E served as the low, high, low dose recovery and high dose recovery group respectively. Group B were administered with 10mg/kg body weight of Cannabis sativa leave aqueous extract for 28 days. Group C were administered with 20mg/kg body weight of Cannabis sativa leave aqueous extract for 28 days. Group D was administered with 10mg/kg body weight of Cannabis sativa leave aqueous extract for 28days and were allowed for further 28 days without any administration while group E received 20mg/kg body weight of Cannabis sativa for 28 days and were allowed for further 28days without administration. Groups D and E represent the recovery groups. Group A, B and C were sacrificed a day after their last intubation. The result of the study showed that administration of Cannabis sativa led to a non-significant increase in MDA and a corresponding significant reduction in SOD and CAT levels in the experimental groups compared to the control group A. This is a pointer to the presence oxidative stress. It can therefore be concluded that there were dose and time dependent toxic effects of Cannabis sativa in the model animals.
References (71)
- 1 Colorimetric assay of catalase [DOI]
- 2 Glutathione Metabolism and Its Implications for Health [DOI]
- 3 Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling [DOI]
- 4 Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases [DOI]
- 5 The influence of immaturity on hypoxic‐ischemic brain damage in the rat [DOI]
- 6 Microglial Interactions with Synapses Are Modulated by Visual Experience [DOI]
- 7 Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects [DOI]
- 8 Persistent cannabis users show neuropsychological decline from childhood to midlife [DOI]
- 9 The pharmacokinetics and the pharmacodynamics of cannabinoids [DOI]
- 10 Activity-Dependent Structural and Functional Plasticity of Astrocyte-Neuron Interactions [DOI]
- 11 National Estimates of Marijuana Use and Related Indicators — National Survey on Drug Use and Health, United States, 2002–2014 [DOI]
- 12 Autophagy: A Critical Regulator of Cellular Metabolism and Homeostasis [DOI]
- 13 Long-Term Effects of Cannabis on Brain Structure [DOI]
- 14 Activity-Dependent Regulation of Synapses by Retrograde Messengers [DOI]
- 15 Substance use and withdrawal: Neuropsychological functioning over 8 years in youth [DOI]
- 16 Medical marijuana laws and adolescent marijuana use in the USA from 1991 to 2014: results from annual, repeated cross-sectional surveys [DOI]
- 17 Effects of Cannabis on the Adolescent Brain [DOI]
- 18 Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory [DOI]
- 19 The neuropsychopharmacology of cannabis: A review of human imaging studies [DOI]
- 20 Pharmacokinetics of Cannabinoids [DOI]
- 21 Cannabis Phenolics and their Bioactivities [DOI]
- 22 Biological Electron Microscopy: Theory, Techniques, and Troubleshooting
- 23 Cannabis use and cognitive function: 8‐year trajectory in a young adult cohort [DOI]
- 24 What is the Current Knowledge About the Cardiovascular Risk for Users of Cannabis-Based Products? A Systematic Review [DOI]
- 25 Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors [DOI]
- 26 Locomotor activity modulates associative learning in mouse cerebellum [DOI]
- 27 Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats [DOI]
- 28 Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood [DOI]
- 29 Evaluation of CB1 Receptor Knockout Mice in the Morris Water Maze [DOI]
- 30 Synthetic and plant‐derived cannabinoid receptor antagonists show hypophagic properties in fasted and non‐fasted mice [DOI]
- 31 Combined and Independent Effects of Chronic Marijuana Use and HIV on Brain Metabolites [DOI]
- 32 Cannabis: An Overview of its Adverse Acute and Chronic Effects and its Implications [DOI]
- 33 Withdrawal from THC during adolescence: Sex differences in locomotor activity and anxiety [DOI]
- 34 Protective effect of Allium sativum (garlic) aqueous extract against lead-induced oxidative stress in the rat brain, liver, and kidney [DOI]
- 35 Cannabinoids Activate Monoaminergic Signaling to Modulate KeyC. elegansBehaviors [DOI]
- 36 Verbal Memory, Learning, and Executive Functioning Among Adolescent Inhalant and Cannabis Users [DOI]
- 37 Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults [DOI]
- 38 Executive control among adolescent inhalant and cannabis users [DOI]
- 39 Neurocognitive SuperAging in Older Adults Living With HIV: Demographic, Neuromedical and Everyday Functioning Correlates [DOI]
- 40 Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro [DOI]
- 41 Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis [DOI]
- 42 Glutathione peroxidase activity modulates recovery in the injured immature brain [DOI]
- 43 Endocannabinoid signaling in neurotoxicity and neuroprotection [DOI]
- 44 Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans [DOI]
- 45 Influence of Environment on Sexual Expression in Hemp [DOI]
- 46 The Relationship of Neuropsychological Functioning to Measures of Substance use in an Adolescent Drug Abusing Sample [DOI]
- 47 Effect of a single intrastriatal rotenone injection on oxidative stress and neurodegeneration in the rat brain [DOI]
- 48 Non-cannabinoid constituents from a high potency Cannabis sativa variety [DOI]
- 49 Chronic Marijuana Smoking Does Not Negatively Impact Select Blood Oxidative Stress Biomarkers in Young, Physically Active Men and Women [DOI]
- 50 Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice [DOI]
- 51 Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives [DOI]
- 52 Endocannabinoid signaling in astrocytes [DOI]
- 53 Cannabidiol induces autophagy via ERK1/2 activation in neural cells [DOI]
- 54 Estimation of the number of synapses in the hippocampus and brain-wide by volume electron microscopy and genetic labeling [DOI]
- 55 The phytochemical diversity of commercial Cannabis in the United States [DOI]
- 56 Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease [DOI]
- 57 Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review [DOI]
- 58 A Comprehensive Phytochemical Analysis of Terpenes, Polyphenols and Cannabinoids, and Micromorphological Characterization of 9 Commercial Varieties of Cannabis sativa L. [DOI]
- 59 Cannabis Exposure is Associated With a Lower Likelihood of Neurocognitive Impairment in People Living With HIV [DOI]
- 60 Correlative x-ray phase-contrast tomography and histology of human brain tissue affected by Alzheimer’s disease [DOI]
- 61 Neurological Benefits, Clinical Challenges, and Neuropathologic Promise of Medical Marijuana: A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination [DOI]
- 62 Phytochemical characterization and biological properties of two standardized extracts from a non‐psychotropic Cannabis sativa L. cannabidiol ( CBD )‐chemotype [DOI]
- 63 ‘Cannabis’ ontologies I: Conceptual issues with Cannabis and cannabinoids terminology [DOI]
- 64 Study of Cannabis Oils Obtained from Three Varieties of C. sativa and by Two Different Extraction Methods: Phytochemical Characterization and Biological Activities [DOI]
- 65 Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice [DOI]
- 66 Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination [DOI]
- 67 Marijuana Use and Cognitive Function in HIV-Infected People [DOI]
- 68 The Implications of Cannabinoid-Induced Metabolic Dysregulation for Cellular Differentiation and Growth [DOI]
- 69 Effect of Carica papaya Leaves and Seeds on Electrolyte and Hematological Parameters in Albino Wistar Rats Exposed to Lead Nitrate [DOI]
- 70 Folic Acid Reverses the Effects of Cannabis on the Brain of New Born Wistar Rats [DOI]
- 71 Evaluation of the Antioxidant Capacity and Studies of the Anticonvulsant Properties of Hymenocardia acida [DOI]
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