Effect of Antiasthma Medication on Blood Eosinophil Count and Serum Immunoglobulin E Levels: A Randomized Controlled Study
Wasim A. Wani, Sheeraz A. Dar, Khalid M. Kawosa, Mudasir Nazir, Ikhlas Ahmad, Asif Ahmed
Journal of Advances in Medicine and Medical Research · pp. 33–39 · Published 5 May 2020
10.9734/jammr/2020/v32i630430Abstract
Background: Asthma is a chronic inflammatory condition of lung airways resulting in episodic airflow obstruction. Aims: The main objective of this study is to find the effect of antiasthma medication on serum IgE levels and blood eosinophil count. Study Design: This randomized controlled trial study was performed in children aged 6-15 years of age, with clinically stable and moderate persistent asthma. Results: The findings of this study indicate both group (Budesonide/formoterol group and budesonide group) patients experienced a significant decrease in serum IgE levels and blood eosinophil counts over the study period. However, the difference in two groups was not statistically significant. Conclusions: Inhaled steroids are effective in controlling systemic inflammation in asthma as evidenced by a decrease in IgE levels and eosinophil counts. However addition of LABA doesn’t have any additive effect.
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