Are Children Who Grow Up on Traditional Farms Protected From Asthma, Allergic Rhinitis and Allergic Sensitization?
Asian Journal of Medicine and Health · pp. 1–11 · Published 22 Nov 2016
10.9734/AJMAH/2016/30038Abstract
Epidemiological studies have revealed that children who grow up on traditional farms are protected from asthma, hay fever and allergic sensitization. It has been speculated that allergic diseases may replace infectious diseases in developing countries and should be prioritized and treated as a major public health problem. Exposure to farming materials at early life such livestock, mostly cattle, pigs and poultry; contact with animal feed such as hay, grain, straw and silage; and the consumption of unprocessed cow’s milk have been identified as most farm protective elements. This review discusses the evidences supporting the claim that children from rural areas who grow up on farms are at a significantly lower risk of developing these conditions than children who live in the same rural area but do not grow up on farms.
References (34)
- 1 Asthma and Wheezing in the First Six Years of Life [DOI]
- 2 The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases [DOI]
- 3 Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children [DOI]
- 4 Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey [DOI]
- 5 Innate immunity of the newborn: basic mechanisms and clinical correlates [DOI]
- 6 Reduced risk of hay fever and asthma among children of farmers [DOI]
- 7 Interaction of TNF with TNF Receptor Type 2 Promotes Expansion and Function of Mouse CD4+CD25+ T Regulatory Cells [DOI]
- 8 Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells [DOI]
- 9 Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78 [DOI]
- 10 Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children [DOI]
- 11 Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties [DOI]
- 12 Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe [DOI]
- 13 Which aspects of the farming lifestyle explain the inverse association with childhood allergy? [DOI]
- 14 Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health [DOI]
- 15 Farm exposurein uteromay protect against asthma, hay fever and eczema [DOI]
- 16 Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: The PASTURE Study [DOI]
- 17 Modification of the Inflammatory Response to Allergen Challenge after Exposure to Bacterial Lipopolysaccharide [DOI]
- 18 Pulmonary Function and Symptoms after Inhalation of Endotoxin [DOI]
- 19 Longitudinal study of dust and airborne endotoxin in the home. [DOI]
- 20 ‘Booboos’: the study of everyday pain among young children [DOI]
- 21 Microbial exposure, interferon gamma gene demethylation in naïve T‐cells, and the risk of allergic disease [DOI]
- 22 Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization [DOI]
- 23 Interleukin 4 down‐regulates the expression of CD14 in normal human monocytes [DOI]
- 24 Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants [DOI]
- 25 Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties [DOI]
- 26 Levels of Environmental Endotoxin and Prevalence of Atopic Disease [DOI]
- 27 Worker exposures to airborne dust, endotoxin and ?(1,3)-glucan in two New Zealand sawmills [DOI]
- 28 Induction of a type 1 immune response to a recombinant antigen from Mycobacterium tuberculosis expressed in Mycobacterium vaccae [DOI]
- 29 High levels of grass pollen inside European dairy farms: a role for the allergy‐protective effects of environment? [DOI]
- 30 Specific IgE to allergens in cord blood is associated with maternal immunity to Toxoplasma gondii and rubella virus [DOI]
- 31 Modulation of dendritic cell function by cowshed dust extract [DOI]
- 32 IL-13 down-regulates CD14 expression and TNF-α secretion in normal human monocytes [DOI]
- 33 Is allergic disease programmed in early life? [DOI]
- 34 Endotoxin-tolerant mice produce an inhibitor of tumor necrosis factor synthesis [DOI]
Cited by 1
Henrietta Aritetsoma Ogbunugafor, C. Ugochukwu, A. E. Kyrian-Ogbonna · 2017
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