Effect of Anti-tuberculosis Drugs on Patients with Multi-drug Resistance Tuberculosis in Mainland Hospital Yaba, Lagos, Nigeria

Abstract

Introduction: The occurrence of multi-drug resistance tuberculosis among tuberculosis patients has raised global public health concern, especially in Nigeria. The increase in the number of cases of resistance tuberculosis despite the effort and need to curb the menace in Nigeria led to this study.    Aim of the Study: The aim was to investigate the effect of anti-Tuberculosis drugs on patients with multi-drug resistance Tuberculosis in Mainland Hospital Yaba, Lagos. Materials and Methods: This was a cross-sectional descriptive study of the already confirmed multi-drug resistance tuberculosis patients at the Mainland Hospital Yaba, Lagos .One hundred self-structured interview questionnaires were randomly administered among already confirmed mult-drug resistance tuberculosis patients at the hospital to collect bio-data information, and thereafter, received second- line anti-Tuberculosis drugs in phases for 22 months. Results and Discussion: The patients received the following regimen of treatments based on their weights and ages, the selected regimens administered for 22 months comprised of two phases; first, 8 months of intensive phase of Kanamycin, levofloxacin, cycloserine, prothionamide,and pyrazinamide and second, 12 months of Levofloxacin, cycloserine, prothionamide and pyrazinamide. Post laboratory analysis was used to monitor the effectiveness of the second-line anti-Tuberculosis drugs used. Out of the 92 patients that received the drugs, 89(96.7%) were confirmed negative to multi-drug resistance tuberculosis, while 3(3.3%) were still positive. Conclusion: The anti-Tuberculosis drugs in the order used is highly recommended for the reduction if not total eradication of multi-drug resistance tuberculosis in Nigeria. Effort should be geared towards making sure that the multi-drug resistance tuberculosis patients are confined, proper regimen administered and monitored in order to reduce the rate of spread.