Significance of Some Coagulation Parameters in Women with Unexplained Recurrent Implantation Failures

Abstract

Unexplained recurrent implantation failures are currently a public health problem especially in Sub Saharan Africa. It is a medical condition that has been attributed to many factors including abnormal coagulation. The presented study was conducted to determine the levels of coagulation parameters involving the Platelet count (PLT), Activated Partial Thromboplastin (APTT), Prothrombin Time (PT) and the International Normalized Ratio (INR) in women with unexplained recurrent implantation failures and healthy controls. A total of 80 subjects involving 40 cases and 40 controls aged 20-35 years were recruited for the study. Blood samples were collected from the subjects by venipuncture. The PLT was determined with the Mindray 530BC automated analyzer, Mindray, Japan, the APTT and PT were determined using Haemoscan reagent purchased from Fortress diagnostics, United Kingdom while the INR was calculated from the PT and ISI values. The data was analyzed with SPSS version 23 using Student test. Results were presented as Mean ± SD from the mean and p<0.05 considered as significant. The results revealed significant increase in the PLT (225 ± 41.6) in the women with unexplained recurrent implantation failures compared to PLT (189 ± 26.61) for the control. There was also a significant decrease in APTT (36.6±6.6), PT (10.98±0.7), INR (0.57±0.07) in the women with unexplained recurrent implantation failures compared to APTT (43.4±1.0), PT (16.5±1.2) and INR (1.02±0.18) respectively for the control. This finding supports the claim for abnormal coagulation profile in women with unexplained recurrent implantation failures.