Drug Resistance Patterns of Mycobacterium tuberculosis – Isolates from Indore, India

Abstract

Introduction: Tuberculosis (TB) is an Infectious disease existing pandemically in our world.In parallel, the prevalence of multidrug-resistant tuberculosis (MDR-TB) is also increasing. The TB control programs were not successful due to the emergence of multidrug resistance in M. tuberculosis strains. Objective of the present study was to detect the rate of MDR-MTB in the central state of India. Materials and Methods: The study included all new & old cases of pulmonary & extra pulmonary tuberculosis enrolled between January 2013 and December 2014 carried out in our Indore, lab, India. All the patients’ samples found to be TB positive in our lab were tested by Mycobacterium culture and MTB isolated strains were put for first-line drug-susceptibility testing (DST). MDR-TB was defined as TB caused by bacilli showing resistance to at least isoniazid and rifampicin. Results: A total of 60 MTB isolated strains; fourteen were MDRs (23.3%). Resistance to INH, RIF, PYRA, ETHAM,streptomycin (STREPTO) was found to be 41%, 36.6%, 23.3%, 30%, 25% respectively. Conclusions: MDR-TB prevalence was found to be high among both new & old cases of pulmonary & extra pulmonary tuberculosis cases. Nation-wide and State-wide representative data on prevalence of MDR-TB are lacking in the state of Madhya Pradesh, in India. Efforts needs to be directed towards further continuous surveillance for MDR-TB among newly diagnosed TB cases and old diagnosed cases.