Green Tamarind Extract Catalyzed Synthesis of 4-Amino-1,2,4-Triazole Derivatives and Their In-vitro Antimicrobial Activity

Abstract

In several organic synthesis and chemical transformations, the use of green chemistry has decreased the reaction time and chemical waste. Due to the tremendous advantages of green chemistry, the paper presents the synthesis of benzylidene derivatives of 4-amino-1,2,4-triazole by reacting it with various substituted aldehydes/benzaldehydes using different catalytic amount(ln mL) of tamarind extract/glacial acetic acid as a catalyst by conventional and microwave method.  All the synthesized compounds (1-7) were characterized using spectroscopic techniques viz. UV, IR, and 1H NMR. Antimicrobial activity of all the compounds was done using negative gram bacteria i.e. Pseudomonas aeruginosa, Klebsiella sp., and Enterobacter sp. against standard Ampicillin. Compound 2 containing 4-nitro substitution increased the antimicrobial activity as compared to other Enterobacter sp, but none of them showed better In-vitro antimicrobial potential than standard ampicillin. All the synthesized Schiff bases differed significantly from one another within the range of test concentrations.