Synthesis and Antimicrobial Activities of Novel Aminoalkylated 2H-benzotriazoles
Bharti Bhardwaj, Subhash C. Jain
Chemical Science International Journal · pp. 576–586 · Published 31 Mar 2014
10.9734/ACSJ/2014/9104Abstract
In view of generating new compounds for future drug development, we have synthesized some N-aminoalkylated derivatives of benzo[d][1,2,3]triazole by alkylating benzo[d][1,2,3]triazole in the presence of K2CO3/DMF using 1,6-dibromohexane to obtain the 2-(6-bromohexyl)-2H-benzo[d][1,2,3]triazole (3) as the one of the major product which was then used as an intermediate to synthesize a new series of compounds 4a-j. All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities In vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermis), four Gram-negative bacteria (Echerichia coli, Pseudomonas aeuroginosa, Staphylococcus typhi and Klebsiella pneumoniae) and four fungi (Aspergillus niger, Aspergillus fumigatus, Candida albicans and Aspergillus flavus) strains using Cup plate method.
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