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Dissemination of Carbapenemases in Gram-negative Bacteria in Brazilian Hospitals: A Review

Rafaela Linhares Ponte Rangel, Izabelly Linhares Ponte Brito, Amanda Barbosa Linhares, Antonio Osmundo de Vascelos Neto, Claudio Roberto Ferreira de Sousa, Ana Kelvia Araújo Arcanjo, Maria Gabriela Linhares Ponte, Francisco Cesar Barroso Barbosa

Archives of Current Research International · pp. 167–181 · Published 24 Jan 2025

10.9734/acri/2025/v25i11048

Abstract

Antimicrobial resistance in bacteria with carbapenemase activity is a growing public health problem of global proportions. This integrative review synthesizes data from 26 scientific articles published between 2020 and 2024 to analyze the dissemination and genetic diversity of carbapenemases in Brazil. Data were retrieved from the National Library of Medicine (PubMed) and the regional portal of the Virtual Health Library (BVS). The review highlights significant regional variability in carbapenemase prevalence, with the blaKPC gene being the most frequently identified resistance mechanism across multiple Brazilian states. The identification of novel trends, including the simultaneous presence of blaNDM and blaKPC genes in isolates of Proteus mirabilis and Serratia marcescens, in addition to the observation of blaNDM in Klebsiella aerogenes, highlights the intricate nature of antimicrobial resistance patterns. The state of Pernambuco is notable for reporting the first identification of blaVIM-2 in Acinetobacter baumannii and the blaOXA-23-like and blaOXA-143 genes. These findings emphasize the widespread cohabitation of resistance genes, with mobile genetic elements facilitating intra- and interspecies transfer among Gram-negative bacilli. Understanding this genetic diversity is crucial for developing targeted public health interventions. The study underscores the urgent need for enhanced genomic surveillance, robust infection prevention measures, and strengthened antimicrobial stewardship programs to address the growing threat of multidrug-resistant organisms in Brazil and mitigate their impact on global health.

Carbapenemases carbapenem-resistant enterobacteriaceae carbapenem resistance gram-negative bacilli Brazil

References (23)

  1. 1 Carbapenemase-Producing Organisms: A Global Scourge [DOI]
  2. 2 Association of blaNDM-1 with blaKPC-2 and aminoglycoside-modifying enzyme genes among Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens clinical isolates in Brazil [DOI]
  3. 3 Polymyxin Resistance in Clinical Isolates of K. pneumoniae in Brazil: Update on Molecular Mechanisms, Clonal Dissemination and Relationship With KPC-Producing Strains [DOI]
  4. 4 Carbapenem-resistant Pseudomonas aeruginosa strains: a worrying health problem in intensive care units [DOI]
  5. 5 Prolonged Outbreak of Carbapenem and Colistin-Resistant Klebsiella pneumoniae at a Large Tertiary Hospital in Brazil [DOI]
  6. 6 Increased frequency of blaNDM in a tertiary care hospital in southern Brazil [DOI]
  7. 7 Diagnostic performance of the Xpert Carba-R™ assay directly from rectal swabs for active surveillance of carbapenemase-producing organisms in the largest Brazilian University Hospital [DOI]
  8. 8 Dissemination of NDM-producing bacteria in Southern Brazil [DOI]
  9. 9 Genetic Relatedness of NDM-Producing Klebsiella pneumoniae Co-Occurring VIM, KPC, and OXA-48 Enzymes from Surveillance Cultures from an Intensive Care Unit [DOI]
  10. 10 Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii Associated with Nosocomial Infection in the Pelotas, RS, Brazil [DOI]
  11. 11 High-risk clones of carbapenem resistant Klebsiella pneumoniae recovered from pediatric patients in Southern Brazil [DOI]
  12. 12 Genetic profile and characterization of antimicrobial resistance in Acinetobacter baumannii post-COVID-19 pandemic: a study in a tertiary hospital in Recife, Brazil [DOI]
  13. 13 High mortality by nosocomial infections caused by carbapenem-resistant P. aeruginosa in a referral hospital in Brazil: facing the perfect storm [DOI]
  14. 14 Carbapenem-resistant Klebsiella pneumoniae colonization and infection is associated with lower overall survival in a cohort of haematopoietic stem-cell transplantation patients: mechanism of resistance and virulence by whole-genome sequencing [DOI]
  15. 15 Molecular epidemiology and drug resistance of Acinetobacter baumannii isolated from a regional hospital in the Brazilian Amazon region [DOI]
  16. 16 Overuse of empirical antibiotics in a COVID-19 intensive care unit led to the spread of carbapenem-resistant Gram-negative bacteria in a teaching hospital [DOI]
  17. 17 First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil [DOI]
  18. 18 Occurrence of blaNDM-1, blaNDM-5, blaNDM-7, and blaKPC-2 genes in clinical isolates of enterobacterales with high genetic variability, from colonization and infection in patients with or without COVID-19, from a hospital in Brazil [DOI]
  19. 19 Performance of two methods of carbapenem-resistant Enterobacterales surveillance on a kidney transplant ward: selective culture of and real-time PCR directly from rectal swabs [DOI]
  20. 20 Phenotypic and molecular evaluation of biofilm formation in Klebsiella pneumoniae carbapenemase (KPC) isolates obtained from a hospital of Pelotas, RS, Brazil [DOI]
  21. 21 Emergence of rmtD1 gene in clinical isolates of Pseudomonas aeruginosa carrying blaKPC and/or blaVIM-2 genes in Brazil [DOI]
  22. 22 PSEUDOMONAS AERUGINOSA: PANORAMA DO PERFIL DE RESISTÊNCIA AOS CARBAPENÊMICOS NO BRASIL / PSEUDOMONAS AERUGINOSA: OVERVIEW OF THE PROFILE OF RESISTANCE TO CARBAPENEMS IN BRAZIL [DOI]
  23. 23 Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii from Southern Brazil [DOI]

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