Skip to content
Research Article Open access CC BY 4.0

Dietary Gum Arabic Alleviates Carbon Tetrachloride Induced Liver Fibrosis in Wistar Rats

Mohammed Hamid, Yassin Abdulrahim, Abdelnasir A, Khalid M. Mohammedsalih, Nagmeldin A. Omer, Juma Ahamed Abaker, Hassan M. A. Hejair, Tamour Elkhier, Tagwa Norain Mahmoud, Hidaia B. Zolain

Asian Journal of Research in Animal and Veterinary Sciences · pp. 297–308 · Published 14 Jun 2021

10.9734/ajravs/2021/v4i4159

Abstract

Aims: This study was carried out to investigate the effect of Gum Arabic (GA) on liver fibrosis induced by carbon tetrachloride (CCl4) in Wistar rats. Methods: Rats were randomly divided into three groups (each group: n=8). Group 1 served as untreated control with just 2 ml/kg of olive oil. Group 2 administered only by intraperitoneal (I.P) injection of CCl4 dissolved in olive oil at a dose of 2 ml/kg body weight twice a week for 7 week. Group 3 administered in additional to CCl4 a basal diets containing GA (5%). Results: The outcomes of the current study exhibited that, CCl4 elevated the serum levels of liver enzymes, malondialdehyde (MDA) and hydroxyproline. In addition, CCl4 increase the expression of  inflammatory cytokines TLR-4, TNF-α, IL-6, IL-β1and MCP-1or fibrotic markers cytokines; TGFβ1and α-SMA while decreasing the activity of T-AOC, SOD and GSH-Px . Administration of GA effectively attenuated these changes, in additional to promotion of antioxidants enzymes and reducing the collagen deposition and hepatocytes necrosis. Conclusion: These results suggested that GA has antifibrotic properties and could be used as potential dietary agent against CCl4-induced liver fibrosis in rats.

Gum Arabic carbon tetrachloride liver fibrosis rats

References (33)

  1. 1 Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ [DOI]
  2. 2 Oxidative stress-related molecules and liver fibrosis [DOI]
  3. 3 Hepatic Stellate Cells as a Target for the Treatment of Liver Fibrosis [DOI]
  4. 4 Biological effects of gum arabic: A review of some recent research [DOI]
  5. 5 Alanine aminotransferase as a marker of non‐alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease [DOI]
  6. 6 Liver fibrosis: from the bench to clinical targets [DOI]
  7. 7 Hepatic stellate cells and the reversal of fibrosis [DOI]
  8. 8 PROTECTIVE EFFECTS OF ORAL ARABIC GUM ADMINISTRATION ON GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS [DOI]
  9. 9 Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice [DOI]
  10. 10 Animal models of chronic kidney disease: useful but not perfect [DOI]
  11. 11 Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis.
  12. 12 Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice [DOI]
  13. 13 The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats [DOI]
  14. 14 Relationship between total superoxide dismutase activity with lipid peroxidation, dynamics and morphological parameters in canine semen [DOI]
  15. 15 Mechanisms of hepatic fibrogenesis [DOI]
  16. 16 Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair [DOI]
  17. 17 Amelioration of CCl4-induced liver injury in rats by selenizing Astragalus polysaccharides: Role of proinflammatory cytokines, oxidative stress and hepatic stellate cells [DOI]
  18. 18 Effect of Physalis peruviana L. on Cadmium-Induced Testicular Toxicity in Rats [DOI]
  19. 19 A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats [DOI]
  20. 20 Clinical effects of Arabic gum (Acacia): A mini review [DOI]
  21. 21 Ameliorating effect of gum arabic and lemongrass on chronic kidney disease induced experimentally in rats [DOI]
  22. 22 Hepatoprotective Effects of Phloridzin on Hepatic Fibrosis Induced by Carbon Tetrachloride against Oxidative Stress-Triggered Damage and Fibrosis in Rats [DOI]
  23. 23 Protective role and antioxidant activity of arabic gum againsttrichloroacetate-induced toxicity in liver of male rats [DOI]
  24. 24 The anti‐inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct‐ligated rats [DOI]
  25. 25 Inactivation of Kupffer Cells by Selenizing Astragalus Polysaccharides Prevents CCl4-Induced Hepatocellular Necrosis in the Male Wistar Rat [DOI]
  26. 26 The Effect of Antifibrotic Drug Halofugine on Th17 Cells in Concanavalin A‐Induced Liver Fibrosis [DOI]
  27. 27 Effect of select antioxidants on malondialdehyde modification of proteins [DOI]
  28. 28 Hepatoprotective Activity of Acacia senegal Pod against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
  29. 29 Selenium modifies glutathione peroxidase activity and glutathione concentration in mice exposed to ozone-provoked oxidative stress [DOI]
  30. 30 Hepatoprotective Effect of Gum Arabic in Non-Alcoholic Fatty Liver and Potential Modulation of Intestinal Microbiota (FS07-07-19) [DOI]
  31. 31 Cytokine Regulation of Hepatic Stellate Cells in Liver Fibrosis [DOI]
  32. 32 Alcoholism: Clinical and Experimental Research [DOI]
  33. 33 A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE

Cited by 4

Synergistic effect of Rosemary and Lemon extractions on some physiological and biochemical parameters of CCl4-Stressed male rats

Thaer M. Al-Mushhadani, Haitham L. Al-Hayali, Shaimaa Obaid Mostafa · Bionatura · 2023

Showing 1 of 4 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

28

Page views

0

PDF downloads

4

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.