Development and Validation of UV-Visible Spectrophotometric Method for Estimation of Tacrolimus in Bulk and Pharmaceutical Nanoparticles
Snehal Patel, Chintan Aundhia, Avinash Seth, Nirmal Shah, Dipti Gohil, Ghanshyam Parmar, Sapna Desai, Kartik Pandya
Journal of Pharmaceutical Research International · pp. 238–242 · Published 29 Dec 2021
10.9734/jpri/2021/v33i62B35192Abstract
A UV-visible spectrophotometric method for quantifying tacrolimus in nanoparticles has been developed and validated, and it is accurate, simple, reproducible, and affordable. For drug analysis, optimal conditions have been identified. 291 nm was discovered to be the maximum wavelength (max). In the range of 0.2-1.8 mg/ml, the response was linear (r2 = 0.9989). The intra- and inter-day relative standard deviations for precision studies were found to be less than 2%, indicating that the procedure is precise.
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