Development and Evaluation of Naproxen Sodium loaded Eudragit L-100 Nanocarrier by Emulsification Diffusion Method

Abstract

The purpose of this work is to use the practical Emulsification Diffusion Method (EDM) to reduce the particle size to the nanometer range. The application of carefully engineered materials at this length scale to create new therapeutic and diagnostic modalities is the field of nanomedicine, which unites nanotechnology and medicine.  Eudragit L 100, a polymeric carrier that is frequently used, was prepared into nanometer-sized particles using the emulsification–diffusion method (EDM).  It is necessary to choose the right drug or API (Active Pharmaceutical Ingredient).  So, naproxen Sodium was chosen as a model drug. The procedure involves adding too much water after emulsifying a drug and polymer solution in an aqueous phase that has been saturated with stabilizer. Investigations into how process variables affect the average size of nanoparticles have been carried out. It was made obvious that the kind and concentrations of stabilizer, the speed at which the magnetic stirrer homogenizes, and the polymer concentration all affected the size of the nanoparticles. Using sodium dodecyl sulfate (SDS) as a surfactant, Naproxen Sodium with Eudragit L 100 nanoparticles smaller than 100 nm was obtained using a Scanning Electron Microscopic (SEM) test.  It was discovered that the addition of medications and luminosity did not significantly alter the nanocarrier's morphology. Because of their large surface area and integration of medication, nanocarriers are more effective. The effectiveness of the Emulsification Diffusion Method for enhancing nanoscale particle size reduction is investigated in the study that is being presented.  The Eudragit L 100 nanoparticles were found to vary in size from 1 to 100 nm, confirming the particle size data and demonstrating that the Emulsification Diffusion Method (EDM) is an appropriate technique for the development of the nanocarrier.