Development and Evaluation of α-Arbutin Based Periorbital Depigmentation Hydrogel Patches for Cosmetic Application

Abstract

Aim: The present study aims to formulate and evaluate α-arbutin–based hydrogel patches for periorbital depigmentation and management of under-eye dark circles. Place and Duration of Study: HSK college of pharmacy, Bagalkote. Methodology: Hydrogel patches were prepared using Agar/PVA (F1), Gelatine/PVA (F2), and Pectin (F3) by solvent-casting method. Formulations were evaluated for organoleptic properties, pH, weight, thickness, swelling index, folding endurance, tensile strength, drug content, FTIR compatibility, antioxidant activity, and in-vitro drug release using Franz diffusion cell. Results: FTIR confirmed absence of drug–polymer interaction. F1 showed optimal mechanical properties (tensile strength 2.97 kg; folding endurance 321) and swelling (72.97%). Drug content ranged from 85.10 – 89.12%. F2 exhibited highest drug release (95.72% at 90 min), while F1 showed release (75.49%). Antioxidant activity (DPPH) demonstrated strong scavenging potential. Conclusion: α-Arbutin hydrogel patches were successfully developed with safe pH, good flexibility, enhanced antioxidant activity, and controlled depigmenting agent release. F1 was identified as the most suitable formulation for cosmetic under-eye application.