Development of Functional Matrix systems for core drug delivery in Multiple Unit Pellet System (MUPS)
Manish Kumar Patel, Nandu Rangnath Kayande
South Asian Research Journal of Natural Products · pp. 316–322 · Published 26 Oct 2024
Abstract
The thumbnail of the proposed system permits functional polymer coating on the drug loaded core. Type of coating, percentage of the coating, type of plasticizer used in the coating, thickness of the coat, type of the drug substance plays a mnemonic observance in controlling the drug release and mechanism of the drug release as well. Various drug release transactions are possible in this kind of the system. This system is temptation of the drug embedded in the functional polymer which controls the drug recluses. It can be produced by loading drug solution or dispersion on the core to achieve controlled drug release system. Polymer and drug substance are solubilised in the suitable solvent system which is common to both the raw material and followed by spraying and drying. Additional coating (may be functional or non-functional) may be applied. Diffusion type of drug release mechanism is followed by such kind of the system.
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