Effect of Turmeric (Curcuma longa) Extract with Zinc Oxide Nanoparticles Application on Burn Wound

Abstract

An experiment was conducted at the Department of Physiology and Pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh to see the clinical effectiveness of turmeric extract with zinc oxide (ZnO) nanoparticles in a hot iron burn wound in the rabbit model. Data were collected on the healing rate, healing time, and White blood cells (WBC) count. Sixteen male New Zealand White rabbits were divided into four groups where group T0 served as the non-treated, T1 as burn healing using turmeric extract, T2 burn heals with turmeric extract and ZnO nanoparticles; and T3 burn heals with Bactrocin®. The results showed that the T2 treatment had the best (93±0.707%), T3 better (88.5±1.04%), T1 good (86.5±1.55%) performance, and while the T0 (67.5±0.86%) gave the worst performance. The T3 (26.5±0.60 days) and T2 treatments had the greatest results (24.5±0.6455 days) and required the fewest days of healing compared to T0 which takes a maximum of days (35.5±0.64). The study revealed that the WBC count was maximum in the non-treated group (at 0,1st, 2nd, 3rd, and 4th week) which is (5600±31.06, 9000±36.47, 8000±38.41, 7500±36.11 and 6000±43.11 cell/ul respectively). The T2 treatments showed lower WBC count during the entire studied period (0, 1st and 4th days) and T3 at (3rd week and 4th week). Overall, the results of the study showed that the use of turmeric extract and ZnO nanoparticles led to faster burn wound healing with a shorter time required, proving that treating burn wounds in rabbits without the use of the commercial drug is both feasible and recommended for practice.