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Research Article Open access CC BY 4.0

Current Research Progress in Stem Cell Therapy and Tissue Engineering Using Decellularized Materials

Anjali Oak, Swati Singh, Asim Mustafa Khan, Prateek J. Pachore

Journal of Pharmaceutical Research International · pp. 329–346 · Published 20 Nov 2021

10.9734/jpri/2021/v33i50B33458

Abstract

Aims: The study clearly aims to describe the advancements of the researches that are made of stem cell and tissue engineering. It also aims to provide the objectives of using decellularization. Study Design: The study is based on the secondary qualitative analysis of primary resources collected from previous researches. The systematic review that deals with the solutions of the raised challenges in the PICO model has been performed in this research.  Methodology: Methodology of the study deals with the testing of the uses of stem cells and tissue engineering so that new and innovative methods can be made in the field of tissue and organ transplantation. The methodology also describes the way of the collection of data from several databases. The data has been collected on the basis of the answer of drawn research question in the research.  Results: The result deals with the meta-analysis of the secondary sources chosen for this research. Characterized features of the stem cells and tissue engineering in different filed of the diseases. The result also discusses the factor that there must be the implementation of scaffolds from different organisms. It is thus analysed to be the part of tissue engineering and tissue engineering there must have some developmental stages of the ECM matrix. The implementation of plant tissues has been observed to a promising result. The sections from different field of stem cell therapy has been collected together to bring out advancements in the stem cell therapy.  The findings suggests that to increase the efficacy of the stem cell therapy and tissue engineering cross kingdom connections such as taking decellularized  tissues from plants must be implemented. Conclusion: The study concludes that the uses of stem cells and use of plant scaffold can be determined. It is also concluded in the study that there is not highlighting gaps that have been analysed in the advanced filed of decellularized implementation for stem cell therapy. This means the use of decellularized components, be it for plants or even from animals can bring up better results for the redevelopment of tissue engineering.  

Stem cell tissue engineering decellularization transplantation scaffolds ECM.

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