Synthesis, Spectroscopic Studies and Antimicrobial Activity of Novel Aromatic Hydrazones Derived from 1-Hydralazinophthalazine
Joseph N. Yong, Peter F. Asobo, Kennedy D. Nyongbela, Romanus N. Njong, Oswald N. Nfor
Chemical Science International Journal · pp. 1–10 · Published 3 May 2016
10.9734/ACSJ/2016/26059Abstract
Aims: To synthesize novel Schiff bases, determine their structures by spectroscopic methods including IR, 1H and 13C NMR, single crystal X-ray diffraction and elemental analysis and test them against some selected bacterial strains. Methodology: 1-Hydralazinophthalazine was condensed with 5-methylfurfural and 2-acetylthiophene to form hydrazones. The Schiff bases obtained were screened for antimicrobial activity using the agar-diffusion method. Results: The spectroscopic data indicate the presence an exocyclic C=N and an N-H bond on the hydralazine moiety of the Schiff base. These compounds show moderate activity against the selected bacterial strains Conclusion: Two new Schiff bases were derived from hydralazine hydrochloride and their structures were determined by elemental analysis, single X-ray diffraction method, IR and NMR. These compounds showed moderate antimicrobial activity against some selected bacterial strains compared to amoxicillin and norfloxacin as standards.
Cited by 5
Gary Chinigo, Yiqing Feng, Susan Hoy · Comprehensive Heterocyclic Chemistry IV · 2022
Romanus N. Njong, Bridget N. Ndosiri, Emmanuel N. Nfor · Open Journal of Physical Chemistry · 2018
Balasankar Thirunavukkarasu, Surya Uthrapathy, Kodisundaram Paulrasu · 2024
V. Balamurugan, L. Muruganandam, S. Shankar · Journal of Bio- and Tribo-Corrosion · 2025
Surya Uthrapathy, Balasankar Thirunavukkarasu, Kodisundaram Paulrasu · Results in Chemistry · 2025
Related research
- Antibacterial Activities of Streptomyces collinus and Streptomyces refuineus from Cocoa, Orange and Timber Plantation Soils in Akure Metropolis — shares topic coverage
- Antimicrobial Activity, Phytochemical Screening and Nutrient Analysis of Tetrapleura tetraptera and Piper guineense — shares topic coverage
- Antibacterial and Antibiofilm Properties of the Crude Ethanolic, Methanolic and Aqueous Bark and Seed Extracts of Citrullus lanatus Fruit — shares topic coverage
- Susceptibility of Some Clinically Resistant Bacterial Isolates to Thyme Essential Oil, Chitosan and Lactobacillus reuteri — shares topic coverage
- Antibacterial and Antifungal Effect of Cinnamon — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
5
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.