Costus Root Extract Alleviates Blood Biochemical Derangements of Experimentally-Induced Hypo- and Hyperthyroidism in Mice
Yousry Bolkiny, Ehab Tousson, Afaf El-Atrsh, Mohamed Akela, Eman Farg
Annual Research & Review in Biology · pp. 1–10 · Published 10 May 2019
10.9734/arrb/2019/v31i530063Abstract
Objectives: Thyroid hormones regulate all metabolic activities; therefore, it is not amazing that hepatic; renal dysfunctions and lipid alterations are commonly detected in patients with thyroid disorders. This study estimated some biochemical changes in post pubertal hyperthyroid and hypothyroid mice and their impacts on liver and kidney functions and also on changes in the lipid pattern. In addition, the ameliorating role of Costus root extract supplementation was examined. Material and Methods: A total of 60 male Swiss albino mice were randomly divided into 5 groups; control, control with costus extract, hypo- and hyper-thyroids post-treated with costus root extract. Results: Present results revealed that, a significant increase in serum thyrotropin (TSH), alanine transaminase (ALT) and aspartate transaminase (AST), alkaline phosphatase (ALP), creatinine, urea, potassium, chloride, cholesterol and triglycerides levels in hypothyroid mice compared to control. On the other hand; a significant decrease in serumthyroxine (T4), tri‐iodothyronine (T3), albumin, total protein and calcium ions levels in hypothyroid mice compared to control. In contrast to hypothyroidism, a significant increase in serum T3, ALT, AST, ALP, creatinine, urea, sodium, potassium, chloride and total proteins levels in hyperthyroid mice compared to control. On the other hand; a significant decrease in serum TSH, T4, albumin, calcium ions cholesterol and triglycerides levels in hyperthyroid mice compared to control. Treatments of mice with Costus root extract in both hypo- and hyperthyroidism modulates the measured serum parameters. Conclusions: Our results could propose that the extract of Costus roots can be used as an adjuvant co-therapy in hypo- and hyperthyroidism syndromes with propylthiouracil and Eltroxin replacement therapy, respectively
References (53)
- 1 Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. [DOI]
- 2 Albumin standards and the measurement of serum albumin with bromcresol green [DOI]
- 3 Liver enzyme alteration: a guide for clinicians [DOI]
- 4 p53 Has a Direct Apoptogenic Role at the Mitochondria [DOI]
- 5 Thyroid dysfunction and kidney disease [DOI]
- 6 The relationship between the thyroid gland and the liver [DOI]
- 7 Interactions between thyroid disorders and kidney disease [DOI]
- 8 Levothyroxine Therapy in Patients with Thyroid Disease [DOI]
- 9 New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects [DOI]
- 10 Components of biological variation, including seasonality, in blood concentrations of TSH, TT3, FT4, PRL, cortisol and testosterone in healthy volunteers [DOI]
- 11 Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats [DOI]
- 12 Subclinical Hypothyroidism and Low-Normal Thyroid Function Are Associated With Nonalcoholic Steatohepatitis and Fibrosis [DOI]
- 13 Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones–neurotransmitters and adenosinergic system interactions [DOI]
- 14 Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents [DOI]
- 15 Germacrenes from fresh costus roots [DOI]
- 16 Rosemary extract modulates fertility potential, DNA fragmentation, injury, KI67 and P53 alterations induced by etoposide in rat testes [DOI]
- 17 Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus [DOI]
- 18 Proliferating Cell Nuclear Antigen as a Molecular Biomarker for Spermatogenesis in PTU-Induced Hypothyroidism of Rats [DOI]
- 19 RETRACTED ARTICLE: The cardioprotective effects of L-carnitine on rat cardiac injury, apoptosis, and oxidative stress caused by amethopterin [DOI]
- 20 P53, Bcl-2 and CD68 expression in response to amethopterin-induced lung injury and ameliorating role of l-carnitine [DOI]
- 21 Two Cases of Thyroid Storm-Associated Cholestatic Jaundice [DOI]
- 22 Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4 [DOI]
- 23 Abnormal Results of Liver Function Tests in Patients with Graves’ Disease [DOI]
- 24 Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways [DOI]
- 25 Immunosuppressant drug tacrolimus induced mitochondrial nephrotoxicity, modified PCNA and Bcl-2 expression attenuated by Ocimum basilicum L. in CD1 mice [DOI]
- 26 Hepatic protective effect of grape seed proanthocyanidin extract against Gleevec-induced apoptosis, liver Injury and Ki67 alterations in rats [DOI]
- 27 Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes [DOI]
- 28 Folic acid alleviates oxidative stress and hyperhomocysteinemia involved in testicular dysfunction of hypothyroid rats [DOI]
- 29 Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid [DOI]
- 30 Biochemical and histopathological studies of the PTU-induced hypothyroid rat kidney with reference to the ameliorating role of folic acid [DOI]
- 31 Assessment of Serum Minerals and Electrolytes In Thyroid Patients [DOI]
- 32 Total serum levels of triiodothyronine (T3) thyroxine (T4) and thyrotropine (TSH) in school going children of Dibrugarh district: an endemic goitre region of Assam.
- 33 P53 Expression in Response to Equigan Induced Testicular Injury and Oxidative Stress in Male Rat and the Possible Prophylactic Effect of Star Anise Extracts [DOI]
- 34 The effect of folic acid as an antioxidant on the hypothalamic monoamines in experimentally induced hypothyroid rat [DOI]
- 35 Treatment with folic acid ameliorated the histopathological alterations caused by propylthiouracil-induced hypothyroid rat testes [DOI]
- 36 Evaluation of protective effects of ethanolic extract of Costus speciosus (Koenig) Sm. rhizomes on carbon tetrachloride induced hepatotoxicity in rats
- 37 RETRACTED ARTICLE: Beneficial role of ascorbic and folic acids antioxidants against thyroxin-induced testicular dysfunction in hyperthyroid rats [DOI]
- 38 Thyroidectomy induced hepatic toxicity and possible amelioration by Ginkgo biloba leaf extract [DOI]
- 39 Protective role of folic acid in thyroxine-induced cardiac hypertrophy in hyperthyroid rat [DOI]
- 40 Biochemical Studies in Experimentally Induced- hyperthyroid Rats Treated with Folic and Ascorbic Acid [DOI]
- 41 Histopathological and immunohistochemical alterations in rat heart after thyroidectomy and the role of hemin and ketoconazole in treatment [DOI]
- 42 Different Stages of Hyperthyroidism: Alterations in Proliferation, Apoptosis, and Histology of Female Rat Ovary
- 43 Interrelationship of Heme Oxygenase and the Oxidative Stress in the Cardiac Tissues of Thyroidectomized Rats [DOI]
- 44 Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat. [DOI]
- 45 Ameliorating Role of Folic Acid in Eltroxine Induced Hyperthyroid and Oxidative Stress in Rat Cortex, Hypothalamus and Hippocampus [DOI]
- 46 Thyroxine-induced cardiac hypertrophy: Role of ascorbic acid in treatment [DOI]
- 47 Impact of Thyroid on Liver Metabolism
- 48 Environmental science and pollution research [DOI]
- 49 Clinical Gastroenterology and Hepatology [DOI]
- 50 Brazilian Journal of Pharmaceutical Sciences
- 51 Albumin standards and the measurement of serum albumin with bromcresol green [DOI]
- 52 Histopathological and immunohistochemical studies on the effects of Ethephon on liver and kidney in male rats [DOI]
- 53 International Journal of Current Research [DOI]
Cited by 34
Tarfa Albrahim, Alwin Robert · Environmental Science and Pollution Research · 2020
Showing 11 of 34 known citations — external sources report more than can currently be individually listed.
Related research
- Effect of Crude Ethanol Leaf-extract of Murraya koenigii on Anxiety in Mice — shares topic coverage
- Liver Profile of Artemether-lumefantrine-tinidazole in Healthy and Parasitized Mice — shares topic coverage
- Harnessing Ashitaba Extract: A Promising Solution for Regulating Blood Glucose in High Glucose Diet Mice — shares topic coverage
- Evaluation of Anti-malarial Profile of Methanol Leaf Extract of Jatropha curcas Linn on Plasmodium berghei Infection in Mice — shares topic coverage
- Histological Effect of Static Magnetic Fields on Testis and Epididymis in Male Mice — shares topic coverage
Article metrics
Real usage data collected on this platform.
65
Page views
0
PDF downloads
38
Outbound clicks
34
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.