Coronary Heart Disease Secondary to Familial Hypercholesterolemia: A Fast Killer
Hanane Mechal, Samia Ejjebli, Meryem Haboub, Salim Arous, Mohamed El Ghali Benouna, Abdenacer Drighil, Leila Azzouzi, Rachida Habbal
Asian Journal of Research in Cardiovascular Diseases · pp. 135–143 · Published 18 May 2022
Abstract
Familial hypercholesterolemia is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been shown to be associated with increased coronary heart disease and premature death. We report two cases of homozygote familial hypercholesterolemia (IIa) in brothers, presenting coronary artery disease at an early age, with a very disturbed lipid profile, rapidly progressive and diffuse coronary lesions, with the occurrence of early death in both brothers before the age of 30.
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