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Research Article Open access CC BY 4.0

Comparative Phytochemical, Proximate and In vitro Antihyperglycemic Analyses of the Stem Bark Extracts of Kigelia africana (Lam.) Benth and Annona senegalensis Pers

C. E. Anarado, O. F. Obumselu, N. U. Ejimofor, N. P. Okafor, C. L. Igwe, J. C. Udekute, C. E. Igwe, C. B. Nsofor

Asian Journal of Chemical Sciences · pp. 40–48 · Published 16 Nov 2022

10.9734/ajocs/2022/v12i3222

Abstract

The present research aimed to investigate the phytochemical bioactive constituents and proximate composition of the methanol extract of Kigelia africana and Annona senegalensis stem bark, as well as its in vitro antidiabetic potential. The results suggest that the presence of bioactive compounds may be responsible for the numerous medicinal capacities of these plants, including their antidiabetic abilities. The methanol stem bark extracts of K. africana and A. senegalensis demonstrated strong α-amylase and yeast cell glucose absorption inhibition, respectively. The stem bark methanol extract of A. senegalensis exhibited the highest level of inhibition (87.61%) at 0.1 mg/ml concentration when compared to conventional acarbose medication (56.0%) on the α-amylase enzyme. The percentage of glucose uptake by both methanol stem bark extract of Kigelia africana and Annona senegalensis was recorded maximum (31.40%) at a concentration of 0.5 mg/ml. The present research establishes the antidiabetic effect of methanol stem bark extract of Kigelia africana and Annona senegalensis by in vitro assays.

Kigelia africana Annona senegalensis phytochemicals antihyperglycemic stem bark alpha-amylase inhibition yeast cell glucose uptake

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Cited by 2

Comparative Phytochemical, In-vitro Anti-Hyperglycemic Activities of Napoleona vogelii Hook & Planch Stem Bark and Cassia occidentalis L. Root Extracts

Anarado CE, Anarado CJO, Okonkwo NA, Obumselu OF, Anyanna, KJ, Ikeh OA, Igbokwe IA · Asian Journal of Chemical Sciences · 2024

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