Comparative Hepatoprotective Potential of Tinospora cordifolia, Tinospora sinensis and Neem-guduchi
Bhagyashri Nagarkar, Rohan Kulkarni, Prashant Bhondave, Deepak Kasote, Omkar Kulkarni, Abhay Harsulkar, Suresh Jagtap
Journal of Pharmaceutical Research International · pp. 906–916 · Published 15 Aug 2013
10.9734/BJPR/2013/4003Abstract
Aims: Aim of this study was to evaluate the comparative efficacy of Tinospora cordifolia (Willd.) Miers ex Hook. F., Tinospora sinensis (Lour.) Merrill and T. cordifolia growing on Neem (Azadirachta indica A. Juss.) called Neem-guduchi. Study Design: Selected species have been widely used in the traditional medicine systems in various dosage forms to treat liver disorders. They are of common occurrence and are being used as substitutes to each other. There is no comparative hepatoprotection study yet published, therefore, present study has carried out. Place and Duration of Study: Interactive Research School for Health Affairs, Pune and Amrutvahini College of Pharmacy, Sangamner, between November 2011 and August 2012. Methodology: Guduchi-Satwa, a well-known dosage form was prepared according to the traditional procedure. Hepatoprotective potential was assessed using paracetamol-induced hepatotoxicity model in rats and evaluated by using biochemical parameters viz. alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and total bilirubin (BIL). Results: Both T. cordifolia and T. sinensis Satwa significantly reduced the paracetamol induced elevated levels of serum ALT, AST, ALP and BIL at dose of 200 mg/kg, i.p. as compared to Neem-guduchi. Conclusions: Satwa preparation form of T. sinensis offers exploitable level of hepatoprotection potential.
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