Comparative Evaluation of Antipyretic Activity of an Ayurvedic Herbo-mineral Formulation Dhatryadi Churna and Its Modified Dosage form in Albino Wistar Rats

Abstract

Introduction: Experimental studies are essential and expected part of a new drug development. The studies are conducted to know about the toxic effects (if any), produced by the drug & to access safety of the drug. Studies also help to ascertain the efficacy of the drug & measures to be taken so as to curtail the toxic effects. Aim & Objective: Study was aimed to do comparative evaluation of antipyretic activity of an Ayurvedic herbo-mineral formulation Dhatryadi Churna and its modified dosage form in experimental albino rats. Materials and Methods: Present study was carried out at Animal house attached with the Institute. 24 healthy Albino wistar rats of either sex weighing 180-200 gm were randomly selected and divided into 4 groups. Pyrexia was induced in rat by subcutaneous injection of 10 mL/kg b.w. of a 20% aqueous suspension of brewer's yeast.  The trial drug Dhatryadi Churna and Dhatryadi Vati administered orally in the form of suspension to the albino rats. Observation and Results: The present result shows that the Dhatryadi Churna (DC) and Dhatryadi Vati (DV) have a significant antipyretic effect in yeast induced pyrexia in rats. Hematological parameters were found to be within the normal biological and laboratory limits on comparison with the values of the control group. Conclusion: Dhatryadi churna and Dhatryadi Vati does not show significant adverse effects on the blood, blood cells, and target organs at the doses used and can be safely used in human being.