Coenzyme Q10 Supplementation Reduces Oxidative Stress in Patients with Pre-Eclampsia

Abstract

Objective: To determine the effect of CoQ10 supplementation in reduction of oxidative stress by index marker, Malondialdehyde (MDA), super oxidase dismutase(SOD), catalase(CAT) and glutathione peroxidase (GPx) in patients with pre-eclampsia.  Methodology: A cross-sectional study was conducted at the Department of Biochemistry LUMHS, Jamshoro. During the period of January 2018 to June 2018. Total 200 pregnant women were recruited and divided into two groups. 50 females were normotensive pregnant women as a control group, 150 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken before and after a 3 months’ supplementation to analyse Malondialdehyde (MDA). The CoQ10 was evaluated by High performance liquid chromatography (HPLC-DAD) and MDA, SOD, CAT and GPx were performed on UV- spectrophotometer. Data was analysed by using SPSS version 22. Student t­test was used for analysed of continuous variables. Results: The pre-eclamptic women treated with CoQ10 supplementation the plasma CoQ10 levels and MDA, SOD and CAT levels increased marked after 3 months(p<0.001). But the Glutathione Peroxidase was insignificant results as compared with controls (p=0.057). Conclusion: The present study reflects that supplementation of CoQ10 decreased the oxidative stress and also helpful in improving the health of mother as well of her foetus by increase antioxidant activity.