Latent Toxoplasmosis is Not a Risk Factor for Pregnancy-induced Hypertension
A. A. El-Henawy, H. A. El-Nahas, Mostafa M. Alkhiary
Microbiology Research Journal International · pp. 1–8 · Published 30 Jan 2016
10.9734/BMRJ/2016/23770Abstract
Aims: To compare between Toxoplasma IgG antibody seroprevalence in pregnancy-induced hypertensive females (cases) versus normotensive pregnant females (control), and to identify potential risk factors in Toxoplasma infected patients. Study Design: A prospective case-control study. Place and Duration of Study: Outpatient clinics of Obstetrics & Gynecology Department and Department of Medical Parasitology, faculty of medicine, Mansoura University in the period from January 2013 to February 2014. Methodology: We included 78 pregnant females (39 hypertensive, and 39 normotensive; age range 18-39 years). Data concerning demographic and reproductive histories were recorded including previous pregnancies outcome and foetal complications. Comprehensive investigations of the current pregnancy including clinical examination and abdominal ultrasound scan were performed. Five ml venous blood was withdrawn from each female, processed and investigated for the presence of anti-Toxoplasma IgG antibodies by ELISA. Results: The overall Toxoplasma seroprevalence was 40/78 (51.3%) among total participants. Anti- T. gondii IgG antibodies were found in 23/39 (57.5%) of pregnancy-induced hypertension patients and in 17/39 (42.5%) normotensive controls (OR=1.85; 95% CI: 0.7-4.6; P=.17). Of the anti- T. gondii IgG positive patients, 19 (82.6%) had high IgG levels. In comparison only 1 (6.2%) of the anti- T. gondii IgG positive controls showed high IgG levels (P<.0001). Regarding the specific characteristics of Toxoplasma positive pregnancy-induced hypertension patients, none of those characters displayed a significant correlation with hypertensive tendency except history of abortion (P=.004). Conclusion: Chronic toxoplasmosis is not a likely risk factor for pregnancy-induced hypertension although significantly higher titre among hypertensive females necessitates further research.
References (17)
- 1 Cardiovascular sequelae of preeclampsia/eclampsia: A systematic review and meta-analyses [DOI]
- 2 Prevention of Preeclampsia with Low-Dose Aspirin in Healthy, Nulliparous Pregnant Women [DOI]
- 3 Maternal Exposure to Toxoplasmosis and Risk of Schizophrenia in Adult Offspring [DOI]
- 4 The infectious origins of stillbirth [DOI]
- 5 Pregnancy-Induced hypertension [DOI]
- 6 The immunobiology of the innate response to Toxoplasma gondii [DOI]
- 7 Association Between Maternal Infections and Preeclampsia: A Systematic Review of Epidemiologic Studies [DOI]
- 8 Immunologic Characteristics of Preeclampsia, a Comprehensive Review [DOI]
- 9 Pre-eclampsia is associated with Helicobacter pylori seropositivity in Italy [DOI]
- 10 Helicobacter pylori 's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation [DOI]
- 11 Effects of Latent Toxoplasmosis on Autoimmune Thyroid Diseases in Pregnancy [DOI]
- 12 REVIEW ARTICLE: Toll‐Like Receptor Signaling and Pre‐Eclampsia [DOI]
- 13 Seroepidemiology of Toxoplasma Gondii Infection in Women with First Trimester Spontaneous Miscarriage in Qena Governorate, Egypt [DOI]
- 14 Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis [DOI]
- 15 Low incidence of hypertensive disorders of pregnancy in women treated with spiramycin for toxoplasma infection [DOI]
- 16 Lack of association between Toxoplasma gondii infection and hypertensive disorders in pregnancy: a case–control study in a Northern Mexican population [DOI]
- 17 Pregnancy, immunosupression and reactivation of latent toxoplasmosis [DOI]
Cited by 7
Eman A. A. Hassanen, Dennis Makau, M. Afifi · Frontiers in Veterinary Science · 2023
A. Taman, Samar M. Alhusseiny · 2020
Charles Oluwaseun Adetunji, Olugbemi T. Olaniyan, Inobeme Abel · Next‐Generation Algae · 2023
Charles Oluwaseun Adetunji, Olugbemi T. Olaniyan, Inobeme Abel · Next‐Generation Algae · 2023
Showing 4 of 7 known citations — external sources report more than can currently be individually listed.
Related research
- Perceived Stress and Anxiety in Women during Labour: A Case of Tamale West Hospital, Tamale, Ghana — shares topic coverage
- Mycoplasma genitalium in Infertile and Pregnant Women in Lagos, Nigeria — shares topic coverage
- Asymptomatic Bacteriuria among Pregnant Women at University Hospital in Uyo, Nigeria: Prevalence, Risk Factors and Characteristics — shares topic coverage
- Advancing Exclusive Breastfeeding among HIV-Positive Mothers in Low Resource Settings — shares topic coverage
- Anaemia in Pregnancy at Booking: Prevalence and Risk Factors among Antenatal Attendees in a Southern Nigeria General Hospital — shares topic coverage
Article metrics
Real usage data collected on this platform.
52
Page views
0
PDF downloads
5
Outbound clicks
7
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.