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Research Article Open access CC BY 4.0

Chiral Nonaromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation

Mario Orena, Samuele Rinaldi

Organics · pp. 163–204 · Published 2 Jul 2024

10.3390/org5030009

Abstract

This review deals with the functionalization of double bonds carried out in the presence of a chiral catalyst exploiting the intramolecular attack to haliranium ions by nucleophilic nitrogen of amides or carbamates prepared from achiral aminoalkenes, and the C–N bonds formation leads to highly enantioenriched nonaromatic heterocycles. A range of protocols are reported, emphasizing the synthesis of many natural and biologically active products of pharmacological interest prepared according to this methodology.

Intramolecular force Chemistry Nitrogen Stereochemistry Organic chemistry

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