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Research Article Open access CC BY 4.0

Chemotherapeutic Propensity of Africa Locust Bean (Parkia biglobosa) Seed on Lipid Profile against Potassium Bromate-induced Cardiotoxicity

C. N. Ugwu, C. E. Iwuoha, N. M. Chika-Igwenyi, C. A. Onyeaghala, S. F. Orji, C. Igwenyi, C. L. Uche, O. I. N. Onyekachi, M. U. Nwobodo, I. O. Abali, A. I. Airaodion

Journal of Applied Life Sciences International · pp. 29–38 · Published 5 Sep 2022

10.9734/jalsi/2022/v25i530306

Abstract

Background: Cardiovascular disease cases are on the increase despite many standard medical practices. Some disorders have been successfully treated by medicinal plants. Aim: The current study was designed to assess the chemotherapeutic propensity of Parkia biglobosa against potassium bromate-induced cardiotoxicity. Methodology: Using a soxhlet extractor with ethanol as the solvent, P. biglobosa was extracted. Twenty-four mature male Wistar rats were randomly divided into groups A, B, C, and D after being acclimated in the lab. Oral distilled water was administered to Group A. Although groups C and D likewise received 100 and 200 mg/kg body weight of P. biglobosa, respectively, the animals in groups B, C, and D received 100 mg/kg body weight of potassium bromate (KBrO3). Rats received daily doses of freshly prepared potassium bromate and P. biglobosa extract by oral gavage. After receiving the therapy for 28 days, the animals were slaughtered 24 hours after the last treatment ended while being lightly sedated with diethyl ether. Through a heart puncture, blood was taken. Additionally, the animals' hearts were removed and homogenized. Standard techniques were used to measure the lipid profile parameters. Results: When compared to the untreated group, the plasma levels of total cholesterol, triglycerides, LDL, VLDL, and the CHD risk ratio were significantly higher in the study's animals treated with KBrO3, while HDL and the HDL/LDL ratio were significantly lower. Compared to the control group, administration of KBrO3 significantly decreased cardiac levels of total cholesterol, HDL and HDL/LDL ratio, while increasing levels of triglycerides, LDL, and VLDL, as well as the coronary heart disease (CHD) risk ratio. P. biglobosa attenuated these perturbations in a dose-dependent manner. Conclusion: Potassium bromate caused increase in the levels of triglycerides, LDL, VLDL and a reduction in HDL and HDL/LDL ratio and this effect was found to be attenuated by intake of P. biglobosa. This effect will result in the reduction of CHD risk factors induced by potassium bromate.

African locust bean cardiotoxicity lipid profile potassium bromate

References (47)

  1. 1 Guide for the Care and Use of Laboratory Animals [DOI]
  2. 2 Free Radicals, Antioxidants in Disease and Health [DOI]
  3. 3 Generation of Reactive Oxygen Species, Lipid Peroxidation, and Human Sperm Function [DOI]
  4. 4 The Physical Chemistry of Lipids [DOI]
  5. 5 The Occurrence of Disinfection By‐products in US Drinking Water [DOI]
  6. 6 ABCA1: the gatekeeper for eliminating excess tissue cholesterol [DOI]
  7. 7 A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine [DOI]
  8. 8 Human Biology and Health
  9. 9 Endothelial dysfunction and cardiovascular risk factors [DOI]
  10. 10 Maintenance of the LDL Cholesterol:HDL Cholesterol Ratio in an Elderly Population Given a Dietary Cholesterol Challenge [DOI]
  11. 11 Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats [DOI]
  12. 12 Acetyl-CoA carboxylase exerts strong flux control over lipid synthesis in plants [DOI]
  13. 13 Daily Consumption of a Dark Chocolate Containing Flavanols and Added Sterol Esters Affects Cardiovascular Risk Factors in a Normotensive Population with Elevated Cholesterol [DOI]
  14. 14 Preliminary Phytochemical Screening and Antibacterial Properties of Crude Stem Bark Extracts and Fractions of Parkia biglobosa (Jacq.) [DOI]
  15. 15 Antidiabetic Effect of Ethanolic Extract of Carica papaya Leaves in Alloxan-Induced Diabetic Rats [DOI]
  16. 16 Hepatoprotective Effect of Parkia biglobosa on Acute Ethanol-induced Oxidative Stress in Wistar Rats
  17. 17 Efficacy of Combined Crude Extract of Curcuma longa and Moringa oleifera in the Prevention of Peptic Ulcer in Albino Rats [DOI]
  18. 18 Intracellular cholesterol trafficking. [DOI]
  19. 19 Deleterious effects of potassium bromate administration on renal and hepatic tissues of Swiss mice [DOI]
  20. 20 Toxicity Studies of the Extracts of Parkia biglobosa Stem Bark in Rats [DOI]
  21. 21 Reduction in systemic and VLDL triacylglycerol concentration after a 3-month Mediterranean-style diet in high-cardiovascular-risk subjects [DOI]
  22. 22 Effect of Methanolic Extract of Corchorus olitorius Leaves on Hypoglycemic and Hypolipidaemic Activities in Albino Rats [DOI]
  23. 23 Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats [DOI]
  24. 24 Lemon Juice Elevated Level of Reduced Glutathione and Improved Lipid Profile in Wistar Rats
  25. 25 Evaluation of Potassium Bromate in Bread in Ibadan Metropolis: Fifteen Years after Ban in Nigeria [DOI]
  26. 26 Hypolipidaemic and Antidiabetic Potency of Allium cepa (Onions) Bulb in Alloxan-Induced Diabetic Rats [DOI]
  27. 27 Toxicological assessment of the methanolic leaf extract of Bridelia ferrugelia [DOI]
  28. 28 Hepatoprotective Potency of Ethanolic Extract of Garcinia kola (Heckel) Seed against Acute Ethanol-induced Oxidative Stress in Wistar Rats
  29. 29 Ameliorative Effect of Parkia biglobosa (African Locust Bean) Seed against Potassium Bromate-induced Oxidative Stress [DOI]
  30. 30 Ameliorative Effect of Parkia biglobosa (African Locust Bean) against Egg-Yolk Induced Hypertension
  31. 31 Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues [DOI]
  32. 32 Levofloxacin induced dyslipidemia in male albino rats [DOI]
  33. 33 The influence of diet on protein oxidation [DOI]
  34. 34 Effect of Methanolic Extract of Vernonia amygdalina Leaves on Glycemic and Lipidaemic Indexes of Wistar Rats [DOI]
  35. 35 Antidiabetic Potential of Alkaloid Extracts from Vitex doniana and Ficus thonningii Leaves on Alloxan-induced Diabetic Rats
  36. 36 Assessment of Bread in Ogbomoso Metropolis for the Presence of Potassium Bromate [DOI]
  37. 37 Bigi Soft Drinks might Induce Hyperglycemia and Hyperlipidemia in Wistar Rats
  38. 38 Carcinogenicity of Chloroform in Drinking Water to Male Osborne-Mendel Rats and Female B6C3F1 Mice [DOI]
  39. 39 Hyperglycemic and Hyperlipidemic Effect of Some Coca-Cola Soft Drinks in Wistar Rats [DOI]
  40. 40 Implication of Sugar Intake in Haemorrhoid and Menstruation
  41. 41 Hypolipidemic Propensity of Ethanolic Extract of Xylopia aethiopica Fruit in Wistar Rats
  42. 42 Modulating effects of the red alga Alsidium corallinum against potassium bromate- induced cardiotoxicity in adult mice
  43. 43 International Journal of Bio-Science and Bio-Technology [DOI]
  44. 44 Fundamental and Applied Toxicology [DOI]
  45. 45 1001 chemicals in everyday products [DOI]
  46. 46 International Journal of Research and Reports in Hematology [DOI]
  47. 47 Asian Journal of Research in Cardiovascular Diseases [DOI]

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