Characteristics of Patients Undergoing Open Radical Cystectomy for Management of Muscle Invasive Bladder Cancer in A Tertiary Centre in Egypt

Abstract

Aims: To represent the demographic and functional data of a cohort of patients with invasive bladder cancer managed with Open Radical Cystectomy (ORC) in the Urology Department of Tanta University Hospital between January 2019 and January 2021. Methodology: A retrospective analysis was performed on the records of ORC for the period between January 2019 and January 2021. This cross-sectional study was done in the Urology Department, Tanta University Hospital in Egypt. Results: Data of 47 patients were collected. Most of the patients in were males (34 patients (72.3%), with male to female ratio of 3:1. Most of the patients were either smokers or ex-smokers, while only 18 patients (38.3%) never smoked before. Visible hematuria was the most common symptom at presentation (35 patients) 74.5%. The main radiological imaging used for staging was CT Urography. Most of the tumors were urothelial in 66% of patients. Squamous differentiation was the most common non urothelial variant with 8 patients. The presence of other non-urothelial variant histology was present in 6 patients. Conclusion: This study revealed that in the tertiary hospital of Tanta University, the mean age of patients presented with bladder cancer and undergoing ORC, was 63.5 years. Visible haematuria was the most common complaint reported. The use of MRI is valuable in staging of locally advanced bladder cancer. Most of the tumours were urothelial (66%) with significant reduction in the incidence of squamous cell bladder cancer than the previously reported data. Neoadjuvant chemotherapy has become an integral part of the treatment protocol in cases of muscle invasive bladder cancer.