Changes of Carbonyl Stress Parameters in Rats with Diabetes and Rhabdomyolysis
Kateryna Tokarchuk, Iryna Krysyuk, Sergey Shandrenko
International Journal of Biochemistry Research & Review · pp. 151–159 · Published 20 Feb 2015
10.9734/IJBCRR/2015/15161Abstract
Aim: To investigate the changes of carbonyl stress parameters in rats with combined streptozotocin induced diabetes (STZD, hyperglycemia model) and glycerol stimulated rhabdomyolysis (RM, oxidative stress model). Methodology: RM was induced by glycerol injection and confirmed by changes of heme oxygenase activity, creatine kinase activity, total heme, creatinine, uric acid, urea and bilirubin. STZD was induced by streptozotocin injection and proved by increasing of glucose levels. Carbonyl stress development was determined by total aldehyde levels, TBARS, protein CO group levels, N(6)-Carboxymethyllysine and low-molecular-weight SH groups in blood plasma and liver tissue. Results: A significant increase of carbonyl stress parameters was recorded in RM and STZD rat groups compared with their relative control levels. In animals subjected to the combined induction of RM and STZD, the level of carbonyl stress parameters was lower than that recorded for the STZD and RM groups: total aldehyde levels were decreased in liver resulting in lower TBARS and protein CO group levels. Low-molecular-weight SH groups were increased compared with STZD. Conclusion: Changes of carbonyl stress parameters indicated the significant role of carbonyl stress in diabetes and in rhabdomyolysis. It was demonstrated that combined stimulation of RM and hyperglycemia led to decreasing of carbonyl stress parameters. It can be suggested that these changes in carbonyl stress parameters can be associated with additional initiation of antioxidant defense systems or some compensatory mechanisms.
References (27)
- 1 The Pathobiology of Diabetic Complications [DOI]
- 2 Role of Oxidative Stress in Development of Complications in Diabetes [DOI]
- 3 Protein carbonyl groups as biomarkers of oxidative stress [DOI]
- 4 Rhabdomyolysis and Acute Kidney Injury [DOI]
- 5 Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications [DOI]
- 6 Oxidative Stress in the Pathogenesis of Diabetic Neuropathy [DOI]
- 7 [41] Measurement of protein thiol groups and glutathione in plasma [DOI]
- 8 Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease [DOI]
- 9 Lipid peroxidation: Mechanisms, inhibition, and biological effects [DOI]
- 10 Role of reactive aldehyde in cardiovascular diseases [DOI]
- 11 Oxidative stress and diabetic cardiovascular complications [DOI]
- 12 Role of advanced glycation end products (AGEs) and receptor for AGEs (RAGE) in vascular damage in diabetes [DOI]
- 13 The AGE‐receptor in the pathogenesis of diabetic complications [DOI]
- 14 Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonella foenum graecum) [DOI]
- 15 The Maillard reaction in the human body. The main discoveries and factors that affect glycation [DOI]
- 16 Advanced lipoxidation end-products [DOI]
- 17 Quantification of Bacterial Lipopolysaccharides by the Purpald Assay: Measuring Formaldehyde Generated from 2-keto-3-deoxyoctonate and Heptose at the Inner Core by Periodate Oxidation [DOI]
- 18 Exploring the Biology of Lipid Peroxidation-Derived Protein Carbonylation [DOI]
- 19 High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein [DOI]
- 20 Pigment epithelium-derived factor prevents advanced glycation end products-induced monocyte chemoattractant protein-1 production in microvascular endothelial cells by suppressing intracellular reactive oxygen species generation [DOI]
- 21 Postprandial hyperglycemia and hyperlipidemia-generated glycoxidative stress: its contribution to the pathogenesis of diabetes complications.
- 22 Rhabdomyolysis in the hyperosmolal state [DOI]
- 23 Mutagenicity of acrolein and acrolein-induced DNA adducts [DOI]
- 24 Role of Creatine Supplementation on Exercise‐Induced Cardiovascular Function and Oxidative Stress [DOI]
- 25 Hormonal regulation of heme oxygenase induction in avian hepatocyte culture [DOI]
- 26 Oxidised low density lipoproteins induce iron release from activated myoglobin [DOI]
- 27 The role of aldehydes in development of oxidative stress under rhabdomyolysis in rats [DOI]
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