Procalcitonin as a Marker of Sepsis Due to Bacterial Infection

Abstract

Sepsis is one of the world's health problems that commonly cause mortality. The incidence of sepsis keeps on increasing each year. Many diagnostic parameters for sepsis caused by bacterial infection have been used but sometimes are not specific and misleading. Seeing the high number of sepsis cases needed a prompt and precise diagnostic. Aim: This study aims to evaluate the sensitivity and specificity of procalcitonin in sepsis patients caused by bacterial infection. Method: A cross-sectional study on 54 adult patients with systemic inflammatory response syndrome (12 – 75 years old) in Mitra Keluarga Bekasi Timur Hospital used patients' medical records from October to December 2016. The diagnostic test was analyzed using the receiver operating characteristic curve. Sample: In this study, there were 37 samples, 28 were sepsis patients, and 9 were non-sepsis samples. Finding: The test result of sensitivity and specificity of procalcitonin was 88,5% and 81,8%, cut off value ≥ 0,8, AUC 0,90 with p-value < 0,05. Conclusion: The conclusion is that procalcitonin can be a prompt, ideal, and efficient diagnostic marker for sepsis caused by bacterial infection with high sensitivity and specificity tests.